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[Cisplatin and vinca alkaloid combination chemotherapy of advanced non-small-cell lung cancer in the aged].
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Fifteen patients aged over 65 years of age with advanced non-small-cl lung cancer (mean age = 70.7, stage IIIb: IV = 4:11) were treated with combination chemotherapy consisting of Cisplatin (50 or 80 mg/m2) and a vinca-alkaloid (Vindesine 3 mg/m2 or Etoposide 80 mg/m2). The effectiveness and side
A phase I trial of combination chemotherapy employing carboplatin, vinca alkaloids, with or without bleomycin in patients with advanced malignant tumors.
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A Phase I trial of three carboplatin-based combination chemotherapy regimens was conducted. These included: carboplatin plus vindesine; carboplatin, vindesine, plus bleomycin; and, carboplatin plus vinblastine. Carboplatin was administered every 28 days as an intravenous bolus. The initial dose was
Syndrome of acute dyspnea related to combined mitomycin plus vinca alkaloid chemotherapy.
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We report the incidence, clinical features, and course of acute dyspnea following combination chemotherapy using mitomycin and vindesine or vinblastine. The courses of 387 patients with advanced non-small cell lung cancer receiving combined mitomycin and vinca alkaloid chemotherapy were analyzed. Of
[Combination chemotherapy with bleomycin, vinca alkaloid and cisplatin (BVP) for advanced urothelial cancer].
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Since October 1979, 18 patients with metastatic urothelial cancer have been treated with combination chemotherapy of bleomycin (5-10 mg/day administered on days 1 to 7), vinca alkaloid (vinblastine 5-10 mg/day or vincristine 1 mg/sqm on days 8 and 9) and CDDP (60 mg/sqm on day 10). CR was achieved
Comparison of docetaxel- and vinca alkaloid-based chemotherapy in the first-line treatment of advanced non-small cell lung cancer: a meta-analysis of seven randomized clinical trials.
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BACKGROUND
To compare the impact on overall survival (OS) of docetaxel-based chemotherapy versus vinca alkaloid-based regimens for first-line therapy of advanced non-small cell lung cancer.
METHODS
A meta-analysis of all randomized, controlled trials comparing docetaxel- and vinca alkaloid-based
[Bleomycin, vinca alkaloid and cis-diamminedichloroplatinum combination chemotherapy for advanced testicular tumors].
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Thirteen patients with advanced testicular tumors (seminoma 2, non-seminoma 11) were treated with combination chemotherapy involving BLM, vinca alkaloid and CDDP (BVP) as induction therapy and followed with CPM, VCR and CDDP as maintenance therapy. BVP and COP administration was repeated every 3 and
The chemotherapy of advanced squamous cell carcinomas: long term results obtained with a combination of methotrexate, the vinca alkaloids and bleomycin.
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Long-term results are described in a group of 119 patients treated by a combination of methotrexate, vinca alkaloids and bleomycin and observed over a period of seven years. Details are given of the chemotherapy used, together with modifications designed to reduce its toxicity. There was an overall
Primary prophylaxis with voriconazole in patients receiving induction chemotherapy on the MRC adult acute lymphoblastic leukaemia trial (UK-ALL XII) to avoid itraconazole-enhanced vinca neurotoxicity.
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A phase I trial of combination chemotherapy employing carboplatin vinca alkaloids, with or without bleomycin in patients with advanced malignant tumors.
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[Our experience with Vinca alkaloids in the poly-chemotherapy of inoperable bronchopulmonary cancer].
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[VINCA ALKALOIDS IN ANTINEOPLASM CHEMOTHERAPY].
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Neurotoxicity in cancer chemotherapy: vinca alkaloids.
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Electroanalytical determination of vinca alkaloids used in cancer chemotherapy.
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A differential pulse polarographic method has been developed for determination of the antineoplastic agents vincristine and vinblastine at ng ml level, in biological fluids such as plasma and urine. The vincristine and vinblastine are extracted from urine with Amberlite XAD-2. Linear calibration
Role of chance observations in chemotherapy: Vinca rosea.
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[Current chemotherapeutic trends in the treatment of malignant lymphomas with special reference to Hodgkin's disease].
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Sequential or simulatineous use is made of four types of antiproliferative drugs in the modern treatment of malignant lymphoma: alkylating drugs, including procarbazine; Vinca rosea alkaloids; antibiotics; corticosteroids. The simulataneous employment of two or more drugs appears to give best
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