35 patients that pass the inclusion criteria and do not have exclusion criteria that will receive Vitamin D for 3 days and each time 3 doses of 50000 units

35 patients that will receive placebo for 3 days and each day for 3 doses

Vitamin D Deficiency

Cardiomyopathies

Apoptosis

Inflammation

Participants undergoing coronary artery bypass graft (CABG) surgery are randomly allocated to group A (intervention), who receive 3 doses of vitamin D (50000 U) a day for 3 days before surgery

Vitamin D

Placebo

modarres Hospital

Can Vitamin D Reduce Heart Muscle Damage After Bypass Surgery?

Vitamin D Treatment Attenuates Heart Apoptosis After Coronary Artery Bypass Surgery; A Double-Blind Randomized Placebo-Controlled Clinical Trial

Caspase 2 enzyme activity in right atrial specimen measured by with immunohistochemistry staining

Caspase 3 enzyme activity in right atrial specimen measured by with immunohistochemistry staining

Caspase 7 enzyme activity in right atrial specimen measured by with immunohistochemistry staining

number of pack cell that was administered for the patient

period of time that the patient was on ventilator

Erfan Tasdighi

Principle investigator

Shahid Beheshti University of Medical Sciences

With the exception of the pharmacists, all the investigators, patients and the medical team were blinded to the group allocation.

Authors will include a population of T2DM patients with advanced heart failure and treated by heart transplant.

The patients received in the past heart transplant. In the removed and frizzed hearts authors will extract portions of septal wall. From this tissue authors will analyze inflammatory markers and microRNAs involved in the progression of cardiac disease.

Diabetes Mellitus

Heart Failure

From removed and frozen hearts, authors will conduct a tissue and molecular analysis of possible mechanisms T2DM linked.

xylene/infarkt

Can Vitamin D Reduce Heart Muscle Damage After Bypass Surgery?

Diabetes and Lipid Accumulationand Heart Transplant

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