Journal of Natural Products 1996-Mar

Bioactive ent-kaurene diterpenoids from Annona senegalensis.

Watumiaji waliosajiliwa tu ndio wanaweza kutafsiri nakala

Ingia / Ingia

Kiungo kimehifadhiwa kwenye clipboard

M O Fatope

O T Audu

Y Takeda

L Zeng

G Shi

H Shimada

J L McLaughlin

KIFUNGU: 8882434

DOI: 10.1021/np9601566

BioSeek: 8882434

Maneno muhimu

Kikemikali

Activity-guided fractionation of the stem bark of Annona senegalensis gave four bioactive ent-kaurenoids (1-4). Compound 2 showed selective and significant cytotoxicity for MCF-7 (breast cancer) cells (ED50 1.0 microgram/mL), and 3 and 4 exhibited cytotoxic selectivity for PC-3 (prostate cancer) cells but with weaker potencies (ED50 17-18 micrograms/mL). The structure of the new compound, 3, was deduced from spectral evidence.

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Herbal & Natural Medicine

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Bioactive ent-kaurene diterpenoids from Annona senegalensis.

Maneno muhimu

kaurene

breast neoplasms

saratani

annona

mkonokono

Kikemikali

Hifadhidata kamili ya mimea ya dawa inayoungwa mkono na sayansi