Cardiovascular Research 1977-May

Failure of an antagonist of histamine--chlorpheniramine--to modify the pulmonary vascular response to hypoxia in chronic bronchitis.

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Ingia / Ingia

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R D Stark

R C Joshi

J M Bishop

KIFUNGU: 872161

BioSeek: 872161

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Kikemikali

Experimental evidence from animals suggests that the response of the pulmonary circulation to hypoxia is mediated by histamine. In 3 patients with chronic bronchitis the pulmonary vascular response to hypoxia was measured before and after administration of chlorpheniramine, a competitive antagonist of histamine. No convincing evidence was obtained of a reduction in the size of the response to hypoxia.

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Herbal & Natural Medicine

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