Residual volatile anesthetics after workstation preparation and activated charcoal filtration.

Volatile anesthetics potentially trigger malignant hyperthermia crises in susceptible patients. We therefore aimed to identify preparation procedures for the Draeger Primus that minimize residual concentrations of desflurane and sevoflurane with and without activated charcoal filtration.A Draeger Primus test workstation was primed with 7% desflurane or 2.5% sevoflurane for 2 hours. Residual anesthetic concentrations were evaluated with five preparation procedures, three fresh gas flow rates, and three distinct applications of activated charcoal filters. Finally, non-exchangeable and autoclaved parts of the workstation were tested for residual emission of volatile anesthetics. Concentrations were measured by multicapillary column - ion mobility spectrometry with limits of detection/quantification being <1 part per billion (ppb) for desflurane and <2.5ppb for sevoflurane. Residual volatile anesthetic concentrations <5ppm were assumed to be save.The best preparation procedure included a flushing period of 10 minutes between removal and replacement of all parts of the ventilator circuit which immediately produced residual concentrations <5ppm. A fresh gas flow of 10L/min reduced residual concentration as effectively as 18L/min, whereas flows of 1 or 5L/min slowed washout. Use of activated charcoal filters immediately reduced and maintained residual concentrations <5ppm for up to 24 hours irrespective of previous workstation preparation. The fresh gas hose, circle system, and ventilator diaphragm emitted traces of volatile anesthetics.In elective cases, presumably safe concentrations can be obtained by a 10-minute flush at ≥10L/min between removal and replacement all components of the airway circuit. For emergencies, we recommend using an activated charcoal filter.