The present disclosure provides compositions and methods for alleviating inflammatory-associated diseases and conditions. These methods include administering individual and/or a mixture of multiple flavans isolated from a single or multiple Acacia genus of plants. The present disclosure also includes methods for isolating and purifying from an Acacia genus of plants a composition of flavans having dual specificity for cyclooxygenase (COX-2) and 5-lipoxygenase (5-LO) enzymes.

Jia; Qi

Nichols; Timothy C.

Rhoden; Eric E.

Waite; Scott

Unigen, Inc.

Isolation of a dual COX-2 and 5-lipoxygenase inhibitor from acacia

Isolation of a dual COX-2 and 5-lipdxygenase inhibitor from Acacia

Botanical compounds to modulate kinase activity are disclosed. The compounds and methods disclosed also inhibit expression of COX-2, inhibit synthesis of prostaglandins selectively in target cells, and inhibit inflammatory response selectively. The compositions contain at least one fraction isolated or derived from hops or Acacia.

acacia decussata/inflammation

Isolation of a dual COX-2 and 5-lipoxygenase inhibitor from acacia

Isolation of a dual COX-2 and 5-lipdxygenase inhibitor from Acacia

Protein kinase modulation by hops and Acacia products

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