Disclosed is an isolated nucleic acid molecule comprising a nucleotide sequence that is at least 90% identical to a nucleotide sequence encoding a protein having the amino acid sequence of SEQ ID NO 4, wherein the protein has an aspartic acid (Asp) at amino acid position 106 Transgenic plants comp.pi.sing the nucleic acid have reduced or delayed softening and detenoration of fruit compared to wild-type plants Methods of genetic screening for plants having reduced or delayed softening and detenoration of fruit, isolated oligonucleotides, and a method of imparting to a plant the dfd trait are also disclosed.

Rose; Jocelyn Kenneth

Isaacson-Lustig; Tal

Vrebalov; Julia

Cornell Research Foundation, Inc.

Boyce Thompson Institute for Plant Research

Delayed fruit deterioration allele in plants and methods of detection

The present invention relates generally to Activity Dependent Neurotrophic Factor III (ADNF III), also known as Activity Dependent Neuroprotective Protein (ADNP). More particularly, the present invention relates to nucleic acid sequences encoding ADNF III polypeptides; ADNF III polypeptides encoded by such nucleic acid sequences; antibodies to ADNF III polypeptides; and methods of using such ADNF III polypeptides for the treatment of neurological deficiencies and for the prevention of cell death associated with (1) gp120, the envelope protein from HIV; (2) N-methyl-D-aspartic acid (excito-toxicity); (3) tetrodotoxin (blockage of electrical activity); and (4) .beta.-amyloid peptide, a substance related to neuronal degeneration in Alzheimer's disease.

Ramot University Authority for Applied Research and Industrial Development Ltd.

The United States of America as represented by the Secretary of the Department of Health and Human Services

Activity dependent neurotrophic factor III (ADNF III)

United States of America, as represented by the Secretary of the Department of Health and Human Services

There is provided a motif-specific, context-independent antibody that specifically binds a recurring, modified motif consisting of (i) at least one sumoylated lysine residue, and (ii) one or more degenerate amino acids bound by a peptide bond to said sumoylated lysine residue, said antibody specifically binding said motif in a plurality of non-homologous peptides or proteins within an organism in which it recurs. Also provided is a motif-specific, context-independent antibody that specifically binds a recurring, modified motif consisting of (i) a C-terminal aspartic acid residue, and (ii) one or more degenerate amino acids bound by a peptide bond to said C-terminal aspartic acid residue, said antibody specifically binding said motif in a plurality of non-homologous peptides or proteins within an organism in which it recurs.

Comb; Michael

Guo; Ailan

Rush, II; John Edward

Cai; Jun-Ming

Li; Jing

Zhou; Jing

Cell Signaling Technology, Inc.

Motif-specific and context-independent antibodies that specifically bind to a cleaved caspase motif

aspartic acid

atrophy

aspartic acid/atrophy

Delayed fruit deterioration allele in plants and methods of detection

Activity dependent neurotrophic factor III (ADNF III)

Activity dependent neurotrophic factor III (ADNF III)

Motif-specific and context-independent antibodies that specifically bind to a cleaved caspase motif

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