Treatment group will accept Astragalus Membranaceus(AM) t.i.w treatment for 14 days from second day of admission, in addition to standard ordinary treatment.

Control group will accept placebo t.i.w treatment for 14 days from the second day of admission, in addition to standard ordinary treatment.

Aneurysmal Subarachnoid Hemorrhage

This research is trying to see if AM can enhance the clinical prognosis for spontaneous aneurysm ruptured subarachnoid hemorrhage patients.

Astragalus Membranaceus

Placebo

Astragalus Membranaceus on Aneurysmal Subarachnoid Hemorrhage

Efficacy Study of Astragalus Membranaceus on Aneurysmal Subarachnoid Hemorrhage

evaluating recovery scale percentage at 90 days post discharge following AM treatment for aneurysmal subarachnoid hemorrhage

Interleukin 6, IL-6 in blood and cerebrospinal fluid

Interleukin 1β, IL-1β in blood and cerebrospinal fluid

Tumor Necrosis Factor-α, TNF-α in blood and cerebrospinal fluid

Chun-Chung Chen

Attending Surgeon

China Medical University Hospital

Stroke

Hemorrhagic Transformation Due to Acute Stroke

Astragalus membranaceus ( AM) at a rate of 3 g three times per day

Chinese Herb Astragalus membranaceus

Astragalus Membranaceus for Brain Edema Induced by Hemorrhagic Stroke

The primary outcome measures were the differences in patients' scores on several clinical scales, between baseline (within 7 ± 1 days after the onset of stroke) and week 4 (28 ± 4 days), and between at baseline and week 12 (84 ± 10 days). The scales we used were the Functional Independence Measure scale (FIM), Barthel Index scale (BI), Glasgow Outcome Scale (GOS), and Modified Rankin Scale (MRS). The scores of FIM, BI, GOS, and MRS were assessed by an experienced research nurse.

inflammatory index, which included the levels of C-reactive protein (CRP) and erythrocyte sediment rate (ESR) for venous blood; these were measured at baseline (prior to the first AM dose), and again on the fourth and seventh day of admission; and
Computer tomography (CT) examination, which was done at baseline and on the fourth and seventh days of admission. The ratio of brain edema was calculated by CT (volume of edema divided by blood clot volume)

astragalus/infarction

Astragalus Membranaceus on Aneurysmal Subarachnoid Hemorrhage

Astragalus Membranaceus for Brain Edema Induced by Hemorrhagic Stroke

The Pilot Clinical Study of PG2 Injection on Hemorrhagic Stroke

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