Esophageal Diseases

Dronabinol 5 mg, every other night, orally

Dronabinol

Placebo

Temple University Hospital

Investigation of Cannabinoid Receptor Agonist Dronabinol in Patients With Functional Chest Pain

Patient will fill out a Chest Pain Questionnaire and symptom diary daily of symptoms which will be normalized to a numerical value for comparison among groups.

Patients will fill out a questionnaire pertaining to GERD symptoms which will be normalized to a numerical value for comparison among groups.

A general health-related quality of life questionnaire that examines 8 domains: Physical Functioning, Role Functioning Physical, Role Functioning Emotional, Mental Health, Vitality, Bodily Pain, General Health, and Social Functioning

Sensory thresholds for first sensation, discomfort, and pain in the esophagus. Frequency, amplitude, area under the curve (AUC) of reactive esophageal contractions

Analysis of depressive symptoms normalized to a numerical value for comparison among groups.

Total cholesterol will be measured and reported in mg/dL.

Analysis of anxious symptoms normalized to a numerical value for comparison among groups.

Non-HDL cholesterol will be measured and reported in mg/dL.

HDL cholesterol will be measured and reported in mg/dL.

Triglycerides will be measured and reported in mg/dL.

Glucose will be measured and reported in mg/dL.

Insulin will be measured and reported in µU/mL.

Leptin will be measured and reported in ng/mL.

Leptin will be measured and reported in IU/L.

LDH will be measured and reported in IU/L.

CRP will be measured and reported in mg/L.

cannabis indica/triglyceride

Investigation of Cannabinoid Receptor Agonist Dronabinol in Patients With Functional Chest Pain

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