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13 matokeo

Compounds with high monoamine transporter affinity

Watumiaji waliosajiliwa tu ndio wanaweza kutafsiri nakala

Ingia / Ingia

TECHNICAL FIELD This invention relates to novel compositions with affinity for a monoamine transporter, such as the dopamine, norepinephrine, or serotonin transporter, in brain and in peripheral tissues. BACKGROUND OF THE INVENTION Monoamine transporters play a variety of roles, and compounds with

Compounds with high monoamine transporter affinity

Watumiaji waliosajiliwa tu ndio wanaweza kutafsiri nakala

Ingia / Ingia

TECHNICAL FIELD This invention relates to novel compositions with affinity for a monoamine transporter, such as the dopamine, norepinephrine, or serotonin transporter, in brain and in peripheral tissues. BACKGROUND Monoamine transporters play a variety of roles, and compounds with affinity for the

Piperazino[1,2-a]indol-1-ones and [1,4]diazepino[1,2-a]indol-1-one

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Ingia / Ingia

BACKGROUND OF THE INVENTION Neurogenesis occurs in the developing and adult brain. Conceptually, this process of neurogenesis can be divided into four steps: (i) proliferation of NSCs; (ii) neuronal fate determination of NSC; (iii) survival and maturation of new neurons; and (iv) functional

1,7-naphthyridine derivatives

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Ingia / Ingia

CROSS REFERENCE TO RELATED APPLICATIONS This application is a continuation of International Application No. PCT/EP2014/066123 having an international filing date of Jul. 28, 2014 and which claims benefit under 35 U.S.C. .sctn.119 to European Patent Application No. 13178373.0 filed Jul. 29, 2013. The

Benzisoxazoles

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Ingia / Ingia

BACKGROUND OF THE INVENTION Now it has been shown that the present compounds stimulate neurogenesis from neural stem cells (NSCs). Neurogenesis occurs in the developing and adult brain. Conceptually, this process of neurogenesis can be divided into four steps: (i) proliferation of NSCs; (ii)

Imidazopyridine derivatives

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Ingia / Ingia

The present invention relates to compounds of general formula ##STR00002## wherein Ar is phenyl or pyridinyl; X.sup.1 is N or CH, X.sup.2 is N or CH, with the proviso that only one of X.sup.1 or X.sup.2 is N and the other is CH; R.sup.1 is hydrogen, halogen, lower alkyl, lower alkoxy, lower alkyl

Substituted imidazolyl-alkyl-piperazine and -diazepine derivatives

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Ingia / Ingia

EXAMPLES The following examples and preparations are given to enable those skilled in the art to more clearly understand and to practice the present invention. They should not be considered as a limitation on the scope of the invention, but merely as being illustrative and representative

Isoquinoline derivatives

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Ingia / Ingia

The present invention relates to the use of compounds of general formula ##STR00002## wherein R.sup.1 is phenyl or pyridinyl, which are optionally substituted by halogen, cyano or lower alkyl substituted by halogen, or is dihydro-pyran-4-yl; R.sup.2 is hydrogen or lower alkyl; R.sup.3 is

Pyrido[4,3-B]pyrazine-2-carboxamides as neurogenic agents for the treatment of neurodegenerative disorders

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Ingia / Ingia

FIELD OF THE INVENTION The present invention relates to novel compounds of formula I, wherein R.sup.1, R.sup.2, R.sup.3, and R.sup.4 are as described herein, having pharmaceutical activity, their manufacture, pharmaceutical compositions containing them and their potential use as

Benzimidazoles as CNS active agents

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Ingia / Ingia

The present invention relates to compounds of general formula ##STR00002## wherein R.sup.1 hydrogen, lower alkyl, halogen or lower alkyl substituted by halogen; R.sup.2 is hydrogen or halogen; X.sup.1 is N or CH; X.sup.2 is N or CH; with the proviso that only one of X.sup.1 or X.sup.2 is N; X.sup.3

Urea compounds and their use as enzyme inhibitors

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Ingia / Ingia

FIELD OF THE INVENTION The present invention relates to compounds and their uses, and in particular to compounds and their therapeutic use in the treatment or prevention of conditions having an association with substrates, such as the neurotransmitter anandamide, which are broken down by the fatty

Urea compounds and their use as enzyme inhibitors

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Ingia / Ingia

Fluoro-containing derivatives of hydrogenated pyrido[4,3-b]indoles with neuroprotective and cognition enhancing properties, process for preparing, and use

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Ingia / Ingia

BACKGROUND OF THE INVENTION 1. Field of the Invention This invention relates to chemical compounds in medicine, and more specifically to fluoro-containing derivatives of hydrogenated pyrido[4,3-b]indoles with neuroprotective and cognition enhancing properties, process for preparing and use. 2.

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Herbal & Natural Medicine

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