cytidine/infarction

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Study of the P300 and cerebral maps in subjects with multi-infarct dementia treated with cytidine.

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Ingia / Ingia

A study of event-related P300 potential and cerebral EEG maps was performed in 20 patients affected by multi-infarct dementia (MID): 10 subjects were treated with placebo and 10 with cytidine. The trial was divided into three intervals. The patients, after a period of washout, were evaluated

Treatment of acute cerebral infarction with a choline precursor in a multicenter double-blind placebo-controlled study.

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Ingia / Ingia

A multicenter double-blind placebo-controlled study of cytidine 5'-diphosphocholine (CDP-choline) was conducted to evaluate possible clinical benefits of the drug in patients with acute, moderate to severe cerebral infarction. The patients included also suffered from moderate to mild disturbances of

[Effect of Scalp-acupuncture Treatment on Levels of Serum High-sensitivity C-reactive Protein, and Pro-inflammatory Cytokines in Patients with Acute Cerebral Infarction].

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Ingia / Ingia

OBJECTIVE To observe the influence of scalp acupuncture on levels of high-sensitivity C-reactive protein (hs-CRP), TNF-α, IL-6, and IL-1β levels in patients with acute cerebral infarction (ACl), so as to investigate its mechanism underlying improvement of ACI. METHODS A total of 61 patients with ACI

[Clinical observation on effect of tongnao huoluo acupuncture therapy in treating acute cerebral infarction at ultra-early or acute stage].

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Ingia / Ingia

OBJECTIVE To evaluate the efficacy and safety of Tongnao Huoluo acupuncture (TNHLA) therapy in treating acute cerebral infarction at ultra-early stage (within 6 hrs after attack) or acute stage (within 6-48 hrs after attack). METHODS The effect of TNHLA in the two stages was observed separately

CDP-choline liposomes provide significant reduction in infarction over free CDP-choline in stroke.

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Ingia / Ingia

Cytidine-5'-diphosphocholine (CDP-choline, Citicoline, Somazina) is in clinical use (intravenous administration) for stroke treatment in Europe and Japan, while USA phase III stroke clinical trials (oral administration) were disappointing. Others showed that CDP-choline liposomes significantly

[Clinical medication characteristics of Shuxuening injection in treatment of cerebral infarction research based on registration].

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Ingia / Ingia

To understand the medication characteristics of Xingxue@Shuxuening solutions in the real world, multi-center, large-sample-size registration design method is adopted in this study. Between October 2012 and October 2015, hospitalized patients in 27 medical institutions who used Shuxuening and

Efficacy and Safety of Vinpocetine as Part of Treatment for Acute Cerebral Infarction: A Randomized, Open-Label, Controlled, Multicenter CAVIN (Chinese Assessment for Vinpocetine in Neurology) Trial.

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Ingia / Ingia

OBJECTIVE The objective of this study was to evaluate the efficacy and safety of intravenous vinpocetine administration as part of a comprehensive treatment for acute cerebral infarction in a Chinese population. METHODS 610 acute cerebral infarction patients were randomized into two groups: the

Facial nerve paralysis after impacted lower third molar surgery: a literature review and case report.

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Ingia / Ingia

Facial nerve paralysis (FNP) is the most common cranial nerve disorders and it results in a characteristic facial distortion that is determined in part by the nerves branches involved. With multiples etiologies, these included trauma, tumor formation, idiopathic conditions, cerebral infarct,

Small molecule 2'-deoxycytidine differentiates human umbilical cord-derived MSCs into cardiac progenitors in vitro and their in vivo xeno-transplantation improves cardiac function.

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Ingia / Ingia

Small molecules are widely used to induce stem cell differentiation. 2'-deoxycytidine (2-DC) belongs to the cytidine family. It stimulates the expression of cardiac-specific genes and proteins, and directs mesenchymal stem cells towards cardiomyogenic differentiation. We aim to investigate the role

Mechanism of cardioprotective effect of orotic acid.

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Ingia / Ingia

The pyrimidine base, orotic acid (OA), markedly improves the function of recently infarcted hearts subjected to global ischemia. The mechanism of cardiac action of OA is unclear, but it has been proposed that OA acts by correcting a relative deficiency of nucleotide precursors required for RNA

[Successful treatment of acute myelogenous leukemia in an elderly patient with cytarabine ocfosfate].

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Ingia / Ingia

A 77-year-old female with left hemiplegia caused by cerebral infarction and with mild senile dementia was admitted for further examination of hematological abnormalities. She was diagnosed as acute myelogenous leukemia (AML-M5a) according to French-American-British classification. Since intensive

Effects of citicoline combined with thrombolytic therapy in a rat embolic stroke model.

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Ingia / Ingia

OBJECTIVE We sought to evaluate the effects of the combination of cytidine-5'-diphosphocholine (citicoline) and thrombolysis on infarct size, clinical outcome, and mortality in a rat embolic stroke model. METHODS Eighty-three Sprague-Dawley rats were embolized in the carotid territory with a single

Neuroprotection afforded by prior citicoline administration in experimental brain ischemia: effects on glutamate transport.

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Ingia / Ingia

OBJECTIVE Cytidine-5'-diphosphocholine (citicoline or CDP-choline), an intermediate in the biosynthesis of phosphatidylcholine, has shown beneficial effects in a number of CNS injury models including cerebral ischemia. Citicoline is the only neuroprotectant that has proved efficacy in patients with

CDP-choline at high doses is as effective as i.v. thrombolysis in experimental animal stroke.

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Ingia / Ingia

Use of thrombolysis in acute ischaemic stroke may be limited by a narrow benefit/risk ratio. Pharmacological inhibition of the ischaemic cascade may constitute an effective and safer approach to stroke treatment. This study compared the effects of high doses of cytidine diphosphate-choline

Ischemic brain injury caused by interrupted versus uninterrupted occlusion in hypotensive rats with subarachnoid hemorrhage: neuroprotective effects of citicoline.

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Ingia / Ingia

This study investigated the neuroprotection provided by cytidine 5'-diphosphocholine (citicoline) during interrupted and uninterrupted occlusion of the basilar artery after subarachnoid hemorrhage (SAH) in 121 hypotensive rats. Animals were anesthetized and the basilar artery was exposed through a

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