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Ukurasa 1 kutoka 16 matokeo

Tumor retarding (1,2-diphenyl-ethylenediamine)-platinum(II)-complexes

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Ingia / Ingia

BACKGROUND OF THE INVENTION There are known from German Offenlegungsschrift No. 3405611 antitumor active compounds. Thereby there are described (1,2-diphenyl-ethylenediamine)-platinum (II) complex compounds of the general formula ##STR2## wherein the groups R.sub.1, R.sub.2, R.sub.3, and R.sub.4 are

Substituted diphenyl indanone, indane and indole compounds and analogues thereof useful for the treatment or prevention of diseases characterized by abnormal cell proliferation

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Ingia / Ingia

1. FIELD OF THE INVENTION The present invention relates to aromatic organic compounds which are specific, potent and safe inhibitors of the Ca.sup.2+-activated potassium channel (Gardos channel) of erythrocytes and/or of mammalian cell proliferation. The compounds can be used to reduce sickle

Substituted diphenyl indanone, indane and indole compounds and analogues thereof useful for the treatment of prevention of diseases characterized by abnormal cell proliferation

Watumiaji waliosajiliwa tu ndio wanaweza kutafsiri nakala

Ingia / Ingia

1. FIELD OF THE INVENTION The present invention relates to aromatic organic compounds which are specific, potent and safe inhibitors of the Ca.sup.2+ -activated potassium channel (Gardos channel) of erythrocytes and/or of mammalian cell proliferation. The compounds can be used to reduce sickle

Diphenyl disulfide compounds

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Ingia / Ingia

FIELD OF THE INVENTION This invention relates to novel diphenyl disulfide compounds having the activities to inhibit the production of Interleukin-1.beta. (IL-1.beta.) and the release of Tumor Necrosis Factor.alpha. (TNF.alpha.). BACKGROUND OF THE INVENTION IL-1.beta. is a protein produced mainly

Heterocyclic diphenyl ethers

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Ingia / Ingia

FIELD OF THE INVENTION The present invention relates to novel heterocyclic compounds of the general formula (I), derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, pharmaceutically acceptable salts and pharmaceutically acceptable solvates thereof, and pharmaceutically

Kinase inhibitors and their use in cancer therapy

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Ingia / Ingia

This application is a U.S. national phase application under 35 U.S.C. of .sctn. 371 of International Application No. PCT/EP2016/059918, filed May 3, 2016, which claims priority of European Patent No. 15166458.8, filed May 5, 2015, the disclosure of which is hereby incorporated by reference

1,5-diphenyl-penta-1,4-dien-3-one compounds

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Ingia / Ingia

BACKGROUND Signal Transducer and Activator of Transcription (STAT) proteins are transcription factors that mediate cellular responses to growth factors. These proteins are activated via tyrosine phosphorylation by growth factor receptor-associated tyrosine kinases. Activated STAT proteins promote

Diphenyl derivatives

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Ingia / Ingia

The invention relates to novel diphenyl derivatives, to processes for their preparation and to their use in medicaments. EP-A-580 550 describes oxamic acid derivatives having cholesterol-lowering properties in mammals. The pharmacological property that is emphasized is the reduction of plasma

Certain substituted diphenyl ureas, as modulators of kinase activity

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Ingia / Ingia

Provided herein are certain substituted ureas and related compounds, compositions comprising such compounds, and methods of their use. Protein kinases, the largest family of human enzymes, encompass well over 500 proteins. Kinases play a key role in angiogenesis. Angiogenesis, the formation of new

Diphenyl-triazole derivatives and their use as anti-gestative, immuno-suppressant and anti-tumoral agents

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Ingia / Ingia

OBJECT OF THE PRESENT INVENTION Objects of the present invention are nitrogen heterocyclic aromatic derivatives and their use as anti-gestative, immunosuppressant and anti-tumoral agents. Object of the present invention is also a procedure for the preparation of nitrogen heterocyclic aromatic

Selective estrogen receptor modulators

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Ingia / Ingia

FIELD OF THE INVENTION This invention pertains to triphenylethylene derivatives, such as, 5-{2-[4-(1,2-Diphenyl-but-1-enyl)-phenyl]-vinyl}-1H-tetrazole, as selective estrogen receptor modulators. This invention also provides methods for treating estrogen stimulated diseases in mammals including, but

Platinum complexes derived from b-silyamines

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Ingia / Ingia

BACKGROUND OF THE INVENTION There has been a continuing need for new and more effective chemical agents useful in the treatment of cancers in warm blooded animals, especially in human beings. Indeed, the concentrated effort of the National Cancer Institute over the last several years of their

Diphenylhexene composition for use in treating liver carcinoma and psoriasis

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Ingia / Ingia

This application is a continuation of PCT/EP94/02837, filed Aug. 26, 1994, and designating the United States. The present invention concerns the new chemical compound diphenyl-3-hexene, a process for its production and its use as a therapeutic agent. Numerous diseases in humans are due to an

Specific salt forms of triphenylethylene derivatives as selective estrogen receptor modulators

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Ingia / Ingia

FIELD OF THE INVENTION This invention pertains to novel salt forms of triphenylethylene derivatives, such as 3-[4(1,2-diphenyl-but-1-enyl)-phenyl]-acrylic acid, as selective estrogen receptor modulators. This invention also provides methods for the treatment and/or prevention of estrogen stimulated

Substituted N-(2-arylamino)aryl sulfonamide-containing combinations

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Ingia / Ingia

The present invention relates: to combinations of: component A: one or more omega-carboxyaryl-substituted diphenyl urea compounds of general formula (I), or a physiologically acceptable salt, solvate, hydrate or stereoisomer thereof; component B: one or more N-(2-arylamino)aryl sulfonamide compounds

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