Use of a composition for treating Alzheimer's disease, osteoporosis, sleep apnea, erectile dysfunction, McArdle disease, or a carbohydrate metabolism disorder, or for reducing aging or fatigue. The composition includes a first agent selected from the group consisting of an oxidative phosphorylation inhibitor, an ionophore, and an adenosine 5'-monophosphate-activated protein kinase activator; a second agent that possesses anti-inflammatory activity; and a third agent that possesses serotonin activity.

Chen; Chien-Hung

Treating alzheimer's disease and osteoporosis and reducing aging

Methods of treating chronic arthritis and osteoporosis which utilize both known and novel compounds which would fall under the general formula:wherein A encompasses a wide range of values including but not limited to aryl, loweralkyl, cycloalkyl, and carbohydrates including sucrose and fructose; p is equal to the number of unreacted hydroxy groups contained on the molecule and may be zero; z is the number of --OS(O).sub.2 NR.sup.1 R.sup.2 groups and is always at least one; R.sup.1 and R.sup.2 are selected from hydrogen, loweralkyl, carboxy and the like; a novel process for preparing the compounds is provided wherein an appropriate sulfamic acid aryl ester is reacted with a hydroxy substituted A radical which may or may not contain thereon protected carboxyl, amino or hydroxy substituents, in an aprotic solvent containing a tertiary amine base. Pharmaceutical compositions for the treatment of chronic arthritis and osteoporosis are also provided.

A. H. Robins Company, Incorporated

Compounds having one or more aminosulfonyloxy radicals useful as pharmaceuticals

Compounds having one or more aminosulfaonyloxy radicals useful as pharmaceuticals

The subject invention provides methods and kits for detecting increased bone resorption in patients. These methods and kits use chondroitin sulfate, a glycosaminoglycan, as a marker for bone resorption. Levels of chondroitin sulfate are detected in samples of urine or serum taken from patients. Measurements of chondroitin sulfate levels are made by methods such as fluorophore-assisted carbohydrate electrophoresis (FACE). Knowledge of increased bone resorption rates is useful in diagnosis of bone disorders such as osteoporosis.

osteoporosis/carbohydrate

Treating alzheimer's disease and osteoporosis and reducing aging

Compounds having one or more aminosulfonyloxy radicals useful as pharmaceuticals

Compounds having one or more aminosulfaonyloxy radicals useful as pharmaceuticals

Chondroitin sulfate as a marker of bone resorption

Chondroitin sulfate as a marker of bone resorption

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