osteoporosis/tyrosine

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Ukurasa 1 kutoka 31 matokeo

Method of inhibiting protein tyrosine phosphatase 1B and/or T-cell protein tyrosine phosphatase 4 and/or other PTPases with an Asp residue at position 48

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Ingia / Ingia

FIELD OF THE INVENTION This invention relates to a method of inhibiting Protein Tyrosine Phosphatase 1B (PTP1B) and/or T-cell Protein Tyrosine Phosphatase (TC-PTP) and/or Protein Tyrosine Phosphatases (PTPases) having an aspartic acid (Asp) in position 48 (PTP1B numbering, Chernoff et al., Proc.

Benzo[b]thiophenyl or tetrahydro-benzo[b]thiophenyl modulators of protein tyrosine phosphatases (PTPases)

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Ingia / Ingia

FIELD OF THE INVENTION The present invention relates to novel compounds, to methods for their preparation, to compositions comprising the compounds, to the use of these compounds as medicaments and their use in therapy, where such compounds of Formula 1 are pharmacologically useful inhibitors of

Osteoblast-testicular protein tyrosine phosphatase

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Ingia / Ingia

FIELD OF THE INVENTION The present invention in the field of biochemistry and cell and molecular biology relates to the discovery of a novel transmembrane receptor-type protein tyrosine phosphatase termed osteotesticular protein tyrosine phosphatase (OST-PTP). The cloning and sequencing of the RNA

Tyrosine alkoxyguanidines as integrin inhibitors

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Ingia / Ingia

FIELD OF THE INVENTION The present invention relates to novel tyrosine alkoxyguanidine compounds that are inhibitors of alpha V (.alpha.v) integrins, for example .alpha.v.beta.3 and .alpha.v.beta.5 integrins, their pharmaceutically acceptable salts, and pharmaceutical compositions

Modulators of protein tyrosine phosphatases (PTPases)

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Ingia / Ingia

Modulators of protein tyrosine phosphatases (PTPASES)

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Ingia / Ingia

Modulators of protein tyrosine phosphatases (PTPases)

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Ingia / Ingia

1,2,5-thiazolidine derivatives useful for treating conditions mediated by protein tyrosine phosphatases (PTPase)

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Ingia / Ingia

This application is the National Stage of Application No. PCT/EP2006/046543, filed on Dec. 6, 2006, which claims benefit under 35 U.S.C. .sctn.119(a-d) of U.S. Provisional Application No. 60/748,491, filed Dec. 8, 2005, the contents of which are incorporated herein by reference in their

Thienopyrimidine-based inhibitors of the Src family

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Ingia / Ingia

BACKGROUND OF THE INVENTION 1. Field of the Invention The invention generally relates to the fields of medicinal chemistry and biochemistry. It concerns novel compounds useful for treatment of diseases related to the Src family of tyrosine kinases, methods of synthesis of these compounds and methods

2-amino-6-anilino-purines and their use as medicaments

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Ingia / Ingia

The invention relates to 2-amino-6-anilino-purine derivatives and to processes and novel intermediates for their preparation, pharmaceutical formulations which comprise such derivatives, and the use of these derivatives as medicaments. The invention relates to 2-amino-6-anilino-purine derivatives of

Phosphate mimics and methods of treatment using phosphatase inhibitors

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Ingia / Ingia

FIELD OF THE INVENTION The present invention relates to, inter alia, novel trifluoromethyl sulfonyl and trifluoromethyl sulfonamido compounds, their physiologically acceptable salts and prodrugs, which modulate the activity of protein phosphatases and uses thereof. The invention also relates to the

Ligands for phosphatase binding assay

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Ingia / Ingia

FIELD OF THE INVENTION This invention relates to the use of mutant phosphatase and protease enzymes in a competitive binding assay. Specific examples are the enzymes, tyrosine phosphatase and cysteine protease, e.g. Cathepsin K, and the assay specifically described is a scintillation proximity assay

Class of arylamide compounds useful as inhibitors of c-fms kinase

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Ingia / Ingia

CROSS-REFERENCE TO RELATED APPLICATIONS Not applicable. BACKGROUND OP THE INVENTION 1. Field of the Invention The invention relates to novel compounds that function as protein tyrosine kinase inhibitors. More particularly, the invention relates to novel arylamide and hetereoarylamide compounds that

Inhibitors of c-fms kinase

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Ingia / Ingia

BACKGROUND OF THE INVENTION The invention relates to novel compounds that function as protein tyrosine kinase inhibitors. More particularly, the invention relates to novel compounds that function as inhibitors of c-fms kinase. Protein kinases are enzymes that serve as key components of signal

Inhibitors of c-fms kinase

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Ingia / Ingia

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