Juvenile gout in Taiwan associated with family history and overweight.
Anahtar kelimeler
Öz
OBJECTIVE
To examine the clinical features of juvenile gout and its possible association with familial juvenile hyperuricemic nephropathy (FJHN).
METHODS
A total of 543 cases of juvenile gout from the Ho-Ping Gout Database were enrolled, and 5269 gouty cases with onset age of 40 to 50 years were selected as a control group. Clinical and laboratory data were compared between the 2 groups.
RESULTS
In patients with juvenile gout, body mass index, serum urate concentration, 24-hour urinary uric acid excretion, and creatinine clearance were significantly higher than those in the control group (p < 0.0001), while fractional excretion of uric acid was significantly lower. Only 15% of the juvenile gout cases fulfilled the features of FJHN. The percentage of familial aggregation in juvenile gout was about 1.9-fold higher than that in the control group (44.3% vs 23.8%; p < 0.0001).
CONCLUSIONS
Juvenile gout in Taiwan is associated with overweight and hereditary background, while FJHN may not be primarily responsible.
