Journal of Experimental Medicine 1954-May
Myocardial necrosis produced in animals by means of crystalline streptococcal proteinase.
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Focal myocardial necrosis that was often extensive was found in a high percentage of rabbits, guinea pigs, and mice given a single intravenous injection of crystalline streptococcal proteinase. The findings are discussed in relation to their possible implications for the pathogenesis of the cardiac lesions of rheumatic fever.