Archiv der Pharmazie 2006-Dec
Short and efficient approach towards buxozine-C, an alkaloid from Buxus sempervirens.
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Buxus alkaloids display a wide range of interesting pharmacological activities. Here, we present a short and efficient approach towards one of the alkaloids, buxozine-C. The first synthesis has been achieved with 91% yield starting from cyclovirobuxine-D by forming a tetrahydro-oxazine ring with formaldehyde at room temperature.