The effects of whole green tea infusion on mouse urinary bladder chemical carcinogenesis.
Anahtar kelimeler
Öz
OBJECTIVE
Green tea (GT) is one of the most popular beverages worldwide whose beneficial effects on health have been demonstrated. Recent studies suggest that GT may contribute to reduction of cancer risk and progression. The aim of this study was to evaluate the effects of whole GT on urinary bladder chemical carcinogenesis in male and female ICR mice.
METHODS
The GT characterization was performed using spectrophotometric methods. Urinary bladder lesions were induced using N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) by gavage during 10 weeks and whole GT (0.5%) was provided ad libitum during 20 weeks.
RESULTS
Animals from groups BBN+GT and BBN only developed preneoplastic lesions.
CONCLUSIONS
We did not observe any effects by GT infusion administration on urinary bladder cancer development.
