The impact of standard and autohemochemotherapy for catecholamine levels in the spleen and thymus of rats with sarcoma-45.

The aim of this study was to detect specific features of the effects of the blood-drug complex on catecholaminergic activity of the thymus and spleen. Catecholamine content was quantitatively measured by modified highly sensitive fluorometric method. Standard cyclophosphamide therapy led to tissue "adrenalization" against the background of reduced concentrations of norepinephrine (in the thymus) and dopamine (in both organs). Administration of cyclophosphamide by the autohemochemotherapy method stabilized catecholamine levels in the thymus and spleen of rats. Hence, cyclophosphamide autohemochemotherapy is more effective due to limitation of the destructive "stress" effect of the cytostatic on organs of the immune system.