T1ρ magnetic resonance fingerprinting.

T_1ρ relaxation imaging is a quantitative imaging technique that has been used to assess cartilage integrity, liver fibrosis, tumors, cardiac infarction, and Alzheimer's disease. T₁ , T₂ , and T_1ρ relaxation time constants have each demonstrated different degrees of sensitivity to several markers of fibrosis and inflammation, allowing for a potential multi-parametric approach to tissue quantification. Traditional magnetic resonance fingerprinting (MRF) has been shown to provide quick, quantitative mapping of T₁ and T₂ relaxation time constants. In this study, T_1ρ relaxation is added to the MRF framework using spin lock preparations. An MRF sequence involving an RF-spoiled sequence with T_R , flip angle, T_1ρ , and T₂ preparation variation is described. The sequence is then calibrated against conventional T₁ , T₂ , and T_1ρ relaxation mapping techniques in agar phantoms and the abdomens of four healthy volunteers. Strong intraclass correlation coefficients (ICC > 0.9) were found between conventional and MRF sequences in phantoms and also in healthy volunteers (ICC > 0.8). The highest ICC correlation values were seen in T₁ , followed by T_1ρ and then T₂ . In this study, T_1ρ relaxation has been incorporated into the MRF framework by using spin lock preparations, while still fitting for T₁ and T₂ relaxation time constants. The acquisition of these parameters within a single breath hold in the abdomen alleviates the issues of movement between breath holds in conventional techniques.