The present invention provides compounds and medicines effective for prophylaxis and therapy of various diseases by controlling or inhibiting cell-adhesion. Especially, the compounds of this invention inhibit platelet aggregation action without remarkable elongation of hemorrhagic period and can be used as a safe and long-acting antithrombotic drug as compared with known substances showing the same activity.Compounds of this invention are piperazinones of the formula: ##STR1##wherein the ring A is a basic heterocyclic group; the ring B is a nitrogen containing heterocyclic group or a cyclic hydrocarbon group; Y is CH.sub.2 ; R.sup.1 is H, OH, NH.sub.2 or an hydrocarbon group which may be bound through CO, S, SO or SO.sub.2 ; R.sup.2 is H or a hydrocarbon group; R.sup.3 is an optionally esterified or amidated carboxyl group; and D is a lower alkyl group substituted with an optionally esterified carboxyl group; or a salt thereof.

Takeda Chemical Industries, Ltd.

2-piperazinone-1-acetic acid derivatives and their use

The invention relates to novel amides of [(5,6-dichloro-3-oxo-9a-substituted-2,3,9,9a-tetrahydrofluoren-7-yl)oxy]ac etic acids, their derivatives, and their salts. The compounds are useful for the treatment and prevention of injury to the brain and of edema due to head trauma, stroke (particularly ischemic), arrested breathing, cardiac arrest, Reye's syndrome, cerebral thrombosis, cerebral embolism, the neurological problems caused by AIDS, cerebral hemorrhage, cerebral tumors, encephalomyelitis, spinal cord injury, hydroephalus, post-operative brain injury trauma, edema due to cerebral infections, various brain concussions and elevated intracranial pressure.

Merck &amp; Co., Inc.

Amides of [(5,6-dichloro-3-oxo-9-alpha-substituted-2,3,9,9-alpha-tetrahydrofluoren -7-yl-oxyl]acetic acids, and pharmaceutical compositions thereof

Provided are a cellulose resin composition which can give a cellulose ester film free from the problems with bleeding and has excellent moisture permeability, even when containing a plasticizer in a relatively large amount, and a cellulose resin film which is obtained from the cellulose resin composition. The present invention relates to a cellulose resin composition obtained by adding (A) a polyester plasticizer to a cellulose resin. The aforementioned (A) polyester plasticizer is obtained from a polybasic acid, a glycol and a stopper, wherein 70 to 30 mol % of the aforementioned polybasic acid is a succinic acid and/or an adipic acid; 30 to 70 mol % of the aforementioned polybasic acid is at least one selected from a group consisting of a terephthalic acid, a phthalic acid and an isophthalic acid; the aforementioned glycol is at least one selected from a group consisting of an ethylene glycol, a 1,2-propylene glycol, a 1,3-butanediol and a 2-methyl-1,3-propanediol; the aforementioned stopper is an acetic acid and/or a benzoic acid; and the weight-average molecular weight is 600 to 2,000.

acetic acid/kanama

2-piperazinone-1-acetic acid derivatives and their use

Amides of [(5,6-dichloro-3-oxo-9-alpha-substituted-2,3,9,9-alpha-tetrahydrofluoren -7-yl-oxyl]acetic acids, and pharmaceutical compositions thereof

Cellulose resin composition and cellulose resin film

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