alkaloid/seizures

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Fast profiling of cocaine seizures by FTIR spectroscopy and GC-MS analysis of minor alkaloids and residual solvents.

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In this study, samples coming from large seizures of cocaine which took place in Italian Customs areas during 2011 and 2012 were examined. Minor alkaloids and residual solvents, analyzed by gas chromatography-mass spectrometry (GC-MS) and head space (HS)-GC-MS, respectively, were processed by

Anticonvulsant effects of Fuzi total alkaloid on pentylenetetrazole-induced seizure in mice.

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We investigated the anticonvulsant effect of acute Fuzi total alkaloid (FTA) in seizure induced by the GABAA-receptor antagonist pentylenetetrazole (PTZ). FTA significantly increased the seizure latency and decreased the mortality in PTZ-treated mice. Administration of PTZ increased c-Fos expression

Bacterial alkaloids mitigate seizure-induced hippocampal damage and spatial memory deficits.

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Studies of human patients with temporal lobe epilepsy and animal models of epilepsy have established relationships between seizures, excitotoxic hippocampal damage, and memory impairment. We report that bacterial alkaloids, recently shown to mimic actions of neurotrophic factors in cell culture,

Narcotic antagonism of seizures induced by a dopamine-derived tetrahydroisoquinoline alkaloid.

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This paper describes experiments designed to evaluate whether the narcotic antagonist naloxone significantly interferes with seizures induced by tetrahydroisoquinolines (TIQs). In these experiments we found that naloxone significantly reduced seizure scores induced by intra-cranially infusing mice

[Epileptic seizure-like effect of Sophora alkaloid sophoridine on experimental animals].

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OBJECTIVE To investigate the epileptic seizure-like effect of Sophora alkaloid sophoridine on electroencepholography (EEG) and its possible characteristic and the mechanism of the seizure-like effect. METHODS Chronic electron implantation was employed for the intracranial electroencepholography

[The effect of dihydrated ergot alkaloids on experimentally induced convulsions].

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[Effect of dehydrated ergot alkaloid on hypoglycemic convulsions and death].

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[Effect on audiogenic seizure of white rat of some natural or synthetic alkaloids derived from opium: morphine, dihydro-oxycodeinone, papaverine].

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[Potentiation of experimental camphor, cardiazol and strychnine convulsions following administration of reserpine or whole Rauwolfia serpentina alkaloids].

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Comparative toxicity of coniine, an alkaloid of Conium maculatum (poison hemlock), in chickens, quails, and turkeys.

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Coniine, an alkaloid of Conium maculatum (poison hemlock), was administered by gavage to immature chickens, quails, and turkeys at 0, 25, 50, and 100 mg/kg body weight. At 25 mg coniine/kg body weight, clinical signs were observed only in quails (2/10) and consisted of excitement, depression,

Variation in chemical profiles within large seizures of cocaine bricks.

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Cocaine is usually trafficked from South America throughout the world in packages of approximately one kilogram shaped as bricks and imprinted with a logo. Seizures consisting of multiple cocaine bricks gives the opportunity to examine the variation in the chemical profile within cocaine bricks

Cocaine classification using alkaloid and residual solvent profiling.

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Many different groups of chemical compounds can be used in statistical impurity-profile comparison in order to establish links between different seizures of illicit drugs. For cocaine, some of these compounds descent directly from the coca leaf while others are remnants from the manufacturing

Classification of Opium by UPLC-Q-TOF Analysis of Principal and Minor Alkaloids.

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Opium is the raw material for the production of heroin, and the characterization of opium seizures through laboratory analysis is a valuable tool for law enforcement agencies to trace clandestine opium production and trafficking. In this work, a method for opium profiling based on the relative

Chlorinated opium alkaloid derivatives produced by the use of aqueous sodium hypochlorite during the clandestine manufacture of heroin.

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A clandestine chemist was observed producing heroin from crude morphine utilizing a solution of sodium hypochlorite during the process. Numerous chlorinated opium alkaloid derivatives were created when the morphine acetylation reaction was quenched and neutralized with a solution of sodium

Natural product incarvillateine aggravates epileptic seizures by inhibiting GABAA currents.

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A natural monoterpene alkaloid incarvillateine isolated from the plant Incarvillea sinensis is known to relieve inflammatory and neuropathic pain. However, the molecular target for the action of incarvillateine remains elusive. Here, we report that incarvillateine exacerbates epileptic seizures by

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