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Sensitization and desensitization to allyl isothiocyanate (mustard oil) in the nasal cavity.

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The aim of this study was to investigate the response, acute effects and time-course of sensitization and desensitization to allyl isothiocyanate (mustard oil) nasal stimuli in healthy subjects. Sixty subjects participated in the experiment, which employed psychophysical (intensity ratings) and

Effects of ionized cyclodextrin on decomposition of allyl isothiocyanate in alkaline solutions.

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The secondary hydroxyl ion (alkoxide) ion for cyclodextrin (CD) may affect the decomposition of allyl isothiocyanate (AITC) in alkaline solutions. The equilibrium and kinetic parameters involved in the reaction processes were measured. It was found that the interaction between the alkoxide ion for

Kinetic and thermodynamic analysis of the cyclodextrin-allyl isothiocyanate inclusion complex in an aqueous solution.

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The decomposition of allyl isothiocyanate (AITC) in an aqueous solution was depressed in the presence of cyclodextrin (CD), it's suppression effect increasing in the order of none < beta-CD < alpha-CD. The results of kinetic and thermodynamic analysis of the CD-AITC inclusion complexes showed that

Trigeminal sensitization and desensitization in the nasal cavity: a study of cross interactions.

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Chemical irritation in the human nasal cavity is poorly documented. In this field, an important issue concerns the differential responses produced by successive stimulation. Repeated identical chemical irritant stimuli can produce increases or decreases in responses (two phenomena known as

Photoactivation of olfactory sensory neurons does not affect action potential conduction in individual trigeminal sensory axons innervating the rodent nasal cavity.

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Olfactory and trigeminal chemosensory systems reside in parallel within the mammalian nose. Psychophysical studies in people indicate that these two systems interact at a perceptual level. Trigeminal sensations of pungency mask odour perception, while olfactory stimuli can influence trigeminal

Mechanisms involved in abdominal nociception induced by either TRPV1 or TRPA1 stimulation of rat peritoneum.

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Abdominal pain is a frequent symptom of peritoneal cavity irritation, but little is known about the role of the receptors for irritant substances, transient receptor potential vanilloid 1 (TRPV1) and ankyrin 1 (TRPA1), in this painful condition. Thus, we investigated the abdominal nociception caused

[Effects of pulpal inflammation on the activities of periodontal mechanoreceptive afferent fibers].

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Response properties of periodontal single afferents were investigated in cats with inflammatory irritant-induced pulpitis. A deep dentin cavity was prepared on the right mandibular canine in order to apply an inflammatory agent and small fiber excitant, allyl-isothiocyanate (mustard oil: MO), and

Nasal TRPA1 mediates irritant-induced bradypnea in mice.

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Transient receptor potential ankyrin 1 (TRPA1), a member of the TRP superfamily, exists in sensory neurons such as trigeminal neurons innervating the nasal cavity and vagal neurons innervating the trachea and the lung. Although TRPA1 has been proposed as an irritant receptor that, when stimulated,

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Herbal & Natural Medicine

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