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In vivo induction of apoptosis by fucoxanthin, a marine carotenoid, associated with down-regulating STAT3/EGFR signaling in sarcoma 180 (S180) xenografts-bearing mice.

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Previous in vitro researches have showed that fucoxanthin, a natural carotenoid isolated from sargassum, can inhibit proliferation or induce apoptosis in human neuroblastoma, hepatoma, leukemia, colon carcinoma, prostate cancer or urinary bladder cancer cells. But the precise mechanism by which

A nonsaponification method for the determination of carotenoids, retinoids, and tocopherols in solid human tissues.

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There has been an increasing interest in the measurement of carotenoids, retinoids, and tocopherols in human tissues because some of these micronutrients have been shown to have chemopreventive activity. Since clinical tissue samples obtained for analysis are usually small in quantity, a sensitive

The effect of crocetin on skin papillomas and Rous sarcoma.

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A carotenoid compound, crocetin, was used in two different types of tests involving animal tumors. These tests showed that crocetin both decreased the numbers of tumors as well as delaying onset.

Saffron chemoprevention in biology and medicine: a review.

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A growing body of evidence indicate that carotenoids possess anticarcinogenic, anti-mutagenic and immunomodulating effects. Saffron obtained from the dried stigmas of Crocus sativus L., is an important spice, rich in carotenoids, consumed commonly in different parts of the world. Our laboratory

Anticarcinogenic activity of meso-zeaxanthin in rodents and its possible mechanism of action.

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Anticarcinogenic activity of meso-zeaxanthin (MZ), a xanthophyll carotenoid with profound antioxidant activity, was evaluated against 3-methylcholanthrene (3-MC)-induced sarcoma in mice. Oral administration of MZ at different doses significantly increased tumor latency period. In 3-MC control group,

Protective effects of crocetin on the bladder toxicity induced by cyclophosphamide.

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Cyclophosphamide (CX) has been widely used as an anticancer agent, however obtaining a maximum therapeutic potential for CX has remained a challenge, for generating undesired toxic side effects to the bladder. Crocetin, a natural carotenoid has been employed in the present studies to ameliorate the

Vitamins as hormones.

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Vitamins A and D are the first group of substances that have been reported to exhibit properties of skin hormones, such as organized metabolism, activation, inactivation, and elimination in specialized cells of the tissue, exertion of biological activity, and release in the circulation. Vitamin A

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