200 mg of Hydroxychloroquine orally three times daily for 10 days plus 500 mg of Nitazoxanide orally twice daily for 6 days

Standard care delivered in the COVID-19 isolation hospitals.

COVID-19

Both hydroxychloroquine & nitazoxanide will be administered orally to participating patients

Hydroxychloroquine plus Nitazoxanide

Oxygen administered via ventilator. In addition, antipyretic "paracetamol" may be added if necessary

Standard care

Hydroxychloroquine and Nitazoxanide Combination Therapy for COVID-19

Clinical Trial Evaluating Safety and Efficacy of Hydroxychloroquine and Nitazoxanide Combination as Adjuvant Therapy in Covid-19 Newly Diagnosed Egyptian Patients: A Tanta University Hope

improved breaths per minute for the patients

Serum iron in microgram/dL of the patients

Serum ferritinin microgram/L of the patients

International normalized ratio "INR" for prothrombin time of 2

CBC for lymphocyte count in cells/microliter

Mortality rate [number of dead patients/total number of treated patients]

Prof. Dr. Kamal Mohammed Okasha

Vice-President of Postgraduate Studies and Research Affairs

Tanta University

a double blind randomized controlled parallel study

Patients will be given digoxin orally daily for 24 weeks. The initial dose will be selected with the goal of achieving a serum digoxin concentration of 0.5-0.9 ng/ml, a dose range recommended for heart failure patients. A dose of 0.0625, 0.125 or 0.25 mg daily will be selected based on a normogram.

Polycythemia; Familial

Erythrocytosis; Familial

VHL Gene Mutation

HIF-2alpha Erythrocytosis

PHD2 Erythrocytosis

Chuvash Erythrocyotsis

Digoxin oral route once daily for 24 weeks.

Digoxin

Digoxin for Congenital Erythrocytosis Due to Up-Regulated Hypoxia Sensing

Phase 1 Study of Digoxin for Congenital Erythrocytosis Due to Up-Regulated Hypoxia Sensing

Change in log Epo concentration of 15% or more

The research data will be shared with the co-investigators and the referring physicians.

Victor Gordeuk

Professor of Medicine

University of Illinois at Chicago

Diet modification - nortriptyline and then if necessary topiramate

Diet Modification topiramate and then nortriptyline if necessary

Migraine Disorders

The nortriptyline will be given in an escalating fashion, starting at 25 mg PO qhs for 2 weeks, followed by 50 mg PO qhs for 2 weeks, and finally 75 mg PO qhs. Patients will be encouraged to use the lowest effective dose and to self-titrate their medication.

nortriptyline

Topiramate dosing will be 25 mg PO qhs for 1 week, followed by 25 mg BID for 1 week, followed by 25 mg in the morning and 50 mg qhs for 1 week, and finally 50 mg BID

Topiramate

Saint Louis University

Trial of Nortriptyline and Topiramate in the Initial Treatment of Vestibular Migraine

A Prospective Randomized Cross-over Trial of Nortryptyline and Topiramate in the Initial Treatment of Vestibular Migraine.

Changes in Migraine Specific Quality of LIfe (MSQ) and Dizziness Handicap Inventory (DHI) between groups

Anthony A. Mikulec, MD

Associate Professor

St. Louis University

non-randomized open-label uncontrolled phase II trial

Non-Small Cell Lung Cancer

Brain Metastasis

gefitinib 250mg qd until disease progression or unacceptable toxicity.

digoxin/baş ağrısı

Hydroxychloroquine and Nitazoxanide Combination Therapy for COVID-19

Digoxin for Congenital Erythrocytosis Due to Up-Regulated Hypoxia Sensing

Trial of Nortriptyline and Topiramate in the Initial Treatment of Vestibular Migraine

Efficacy of Gefitinib for Brain Metastasis of Non-Small Cell Lung Cancer

Bilim tarafından desteklenen en eksiksiz şifalı otlar veritabanı