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Bile acids substituted in the 6 position prevent cholesterol gallstone formation in the hamster.

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The aim of the present study is to examine the efficacy of 6-hydroxy substituted bile acids on the prevention of cholesterol gallstones in a new hamster model of cholesterol cholelithiasis. Male golden Syrian hamsters were fed a nutritionally adequate semipurified lithogenic diet consisting of

Dietary induction of cholesterol gallstones in hamsters from three different sources.

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Cholesterol gallstones were produced in young male, golden Syrian hamsters, obtained from three different suppliers, by administering a nutritionally adequate, semipurified diet for periods of either 5 or 10 weeks. The major components of the lithogenic diet were casein, cornstarch, butterfat, corn

Increased dietary fat content accelerates cholesterol gallstone formation in the cholesterol-fed prairie dog.

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Epidemiological studies have provided conflicting information about the relationship between fat consumption and gallstone formation. We studied cholesterol gallstone formation in prairie dogs after 1 wk of the following diets: (group A) a control diet with no added cholesterol and 5% of calories

Plasma cholecystokinin and gallbladder responses to intraduodenal fat in gallstone patients.

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Impaired gallbladder emptying is one of the various factors suggested to be involved in the pathogenesis of gallstones. The present study was undertaken to determine whether gallbladder emptying, endogenous cholecystokinin (CCK) secretion, or their interrelation is altered in patients with

Ethinylestradiol stimulates a biliary cholesterol-phospholipid cosecretion mechanism in the hamster.

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The mechanism of ethinylestradiol-induced biliary secretion of excess cholesterol, a potential causative factor of cholesterol gallstones, is not yet known. It might be related to altered bile acid metabolism, since the rate of cholesterol and phospholipid secreted into bile is thought to be

Disposition, metabolism, and toxicity of methyl tertiary butyl ether, an oxygenate for reformulated gasoline.

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Studies of the toxicology of methyl tertiary butyl ether (MTBE) were reviewed as a possible information base for evaluating the health effects of evaporative emissions from reformulated gasoline (RFG). The major metabolites of the oxidative demethylation of MTBE in vivo were methanol and tertiary

[Effect of dietary fats on serum and aortic lipid levels of mice fed a high-cholesterol diet: a distinct correlation between linoleic acid intake and the lipid changes].

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The effects of dietary linoleic acid on serum lipids, lipid peroxides and aortic cholesterol were studied in mice fed a purified diet enriched with 5% cholesterol for a period of 14 weeks. The diet was supplemented with 10% coconut oil (Group I), lard (Group II), corn oil (Group III) or linoleic

Dietary fat and fatty acids modulate cholesterol cholelithiasis in the hamster.

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We tested two hypotheses, i) whether the type and the amount of fat in the diet will affect the formation of cholesterol gallstones in the hamsters, and ii) whether palmitic acid, a major fatty acid component of butterfat, can act as a potentiator of cholesterol cholelithiasis in the hamster. Young,

Prevention of cholesterol cholelithiasis by dietary unsaturated fats in hormone-treated female hamsters.

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We examined the effect of diet on gallstone incidence and the composition of biliary phosphatidylcholines in methyltestosterone-treated female hamsters. These hamsters were fed a nutritionally adequate purified lithogenic diet containing 2% corn oil, 4% butterfat, 0.3% cholesterol, and 0.05%

Comparison of cholecystokinin release and gallbladder emptying in men and in women at estrogen and progesterone phases of the menstrual cycle.

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Why are gallstones more common in women than in men? To investigate this, we measured gallbladder emptying (by ultrasonography) and release of endogenous cholecystokinin (CCK) (by specific radioimmunoassay) in eight men and nine women in response to ingestion of corn oil (1 gm/kg). Each woman was

Biliary lipids in New World monkeys: dietary cholesterol, fat, and species interactions.

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The separate effects contributed by dietary cholesterol and dietary fat on several parameters of biliary lipid metabolism thought to be important in the genesis of cholesterol gallstones were examined in squirrel and cebus monkeys fed diets containing either corn or coconut oil from birth. Half the

Ethnomedicines used in Trinidad and Tobago for urinary problems and diabetes mellitus.

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BACKGROUND This paper is based on ethnobotanical interviews conducted from 1996-2000 in Trinidad and Tobago with thirty male and female respondents. METHODS A non-experimental validation was conducted on the plants used for urinary problems and diabetes mellitus: This is a preliminary step to

The effect of cholecystectomy on plasma cholecystokinin.

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OBJECTIVE Gallbladder removal is associated with an increased incidence of gastroesophageal reflux, but the mechanism is unclear. Cholecystokinin (CCK) release, which causes gallbladder contraction, is inhibited by bile in the duodenum. This study investigates the effect of cholecystectomy on

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