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Superoxide dismutase 1 is positively selected to minimize protein aggregation in great apes.

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Positive (adaptive) selection has recently been implied in human superoxide dismutase 1 (SOD1), a highly abundant antioxidant protein with energy signaling and antiaging functions, one of very few examples of direct selection on a human protein product (exon); the molecular drivers of this selection

Report of 6(th) Great Wall Translational Andrology and Urology Forum & 7(th) Asian-Pacific Society of Men's Health and Anti-aging Meeting (GTAUF2014 & APSMHA2014).

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A personal tribute to a great educator: how Henry Kawamoto influenced my interest in facial soft tissue anatomy and changed my plastic surgery career.

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Henry Kawamoto remains one of the most influential craniofacial surgeons of the 20th century. A Tessier-trained craniofacial surgeon, Dr. Kawamoto has personally influenced not only the lives of his patients, but significantly also the lives of those craniofacial fellows he educated, passing on the

Relevance of the lesser occipital nerve in facial rejuvenation surgery.

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Nerve injuries are possible during facial rejuvenation surgery. The great auricular nerve has been studied; however, little is known about the lesser occipital nerve and its relevance in facial rejuvenation surgery. To understand the importance of the lesser occipital nerve in a face lift procedure,

Natural products with anti-aging potential: Affected targets and molecular mechanisms.

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In recent years, there has been a great deal of attention toward the molecular machinery relevant to age-related progression controlled through the external intervention of polyphenols- an epigenetic-modulating diet. Natural products modulate cellular longevity through histone post-translational

Botulinum toxin for rejuvenation of the neck.

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The use of botulinum toxin for cosmetically restoring an aging neck is a simple procedure that has great patient satisfaction. It is also a safe and effective therapeutic modality for any patient desiring rejuvenation of his or her neck, but who at the same time does not desire any recuperation time

[Effect on anti-aging and treating yang deficiency of kidney with huanshao dan capsules. A clinical report of 309 cases].

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In this study, with various dosages of huanshao dan capsules, an old Chinese medicine formula, the authors treated the patients with Yang-deficiency of kidney for 1.5-3 months and compared the effects of huanshao dan with those of watered pills and placebo. The analyses of Ridit's showed not only

[Recent anti-aging studies on caloric restriction and resveratrol].

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Seventy-five years after its initial report, lifespan prolongation by caloric restriction (CR) has been confirmed in many animal species. Gathered evidences suggest that the histone deacetylase Sir2/SIRT1 is a key mediator. Moreover, resveratrol (RSV), a plant derived polyphenol, was shown to

[Anti-aging creams. What really helps?].

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As youth and perception of beauty are considered to be of great importance, an increasing number of new cosmeceuticals have been developed in recent years. This article will describe new, evidence-based ingredients against skin-aging; in particular antioxidants (e.g. vitamin C, niacinamide,

Injectable Filler Techniques for Facial Rejuvenation, Volumization, and Augmentation.

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Multiple fillers are available: various hyaluronic acid products, calcium hydroxylapatite, and a few others that are biocompatible with good duration and a variety of mechanical properties allowing intradermal, subdermal, and supraperiosteal injection. Facial features can be reshaped with great

Development of polypyrrole/collagen/nano-strontium substituted bioactive glass composite for boost sciatic nerve rejuvenation in vivo.

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A novel nerve conductor made out of polypyrrole (PPY), collagen (Coll) and nano-strontium substituted bioactive glass (n-Sr@BG) (PPY/Coll/n-Sr@BG) was fabricated by electrospinning. SEM demonstrated that the mean distances across of the pores in the nerve channels were under 15 mm and more prominent

Radiesse(®): a novel rejuvenation treatment for the upper arms.

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Nonsurgical esthetic improvement of the upper arms is a desirable goal for many individuals. Radiesse(®) (calcium hydroxylapatite) is an effective dermal filler for a number of indications because of its volumizing effect and the ability to stimulate neocollagenesis. No studies have reported on its

The extreme arrogance of anti-aging medicine.

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The anti-aging medicine movement proposes to alter the human body in order to achieve extreme longevity. To do this it has to reverse or by-pass the multiple causes of human aging. These include a large number of age-associated pathologies, each of which is being studied in great detail in research

Endoscopic facial rejuvenation.

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The use of an endoscope is a reliable way to perform facial rejuvenation, to correct eyebrow imbalance, periorbital and malar soft-tissue sagginess, and soft-tissue displacement in the lower face and neck. It allows great magnification and tissue dissection control while observing in situ tissue

Use of small RNA as antiaging cosmeceuticals.

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Over the past two decades, RNA interference (RNAi) has achieved great improvements in medicine, which has benefited the development of innovative cosmeceutical products, particular, to antiaging cosmeceuticals. A variety of ongoing research has tried to employ small RNAs-small interference RNA and

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