Group receiving the application of cold on the ventral side of the dominant forearm for 30 seconds, using the technique of ice beakers dynamically.

Group receiving the intervention of "ice bag" for a period of 5 and a half minutes from 1 minute, on the ventral side of the dominant forearm

Group receives a placebo application through an "ice bag" empty. The bag will be applied from 1 minute to 6 and a half minutes, as the group of prolonged cold

Muscle Strength

Brief Application of cold, for a period of up to 30 seconds on a body surface which seeks to promote the activation of the nervous system to produce increased excitability.

Brief Cooling

Prolonged application of cold, for at least 5 minutes or more, on a body surface that aims to reduce nervous system activation by reducing the NCV.

Prolonged Cold

Placebo application through an "ice bag" empty.

Sham Ice Bag

Universidad Andrés Bello

Cold and Isometric Strength

Effects of Brief and Prolonged Cold Application on Maximal Isometric Hand Grip Strength.

Force in kilograms evaluated through manual dynamometry test the time for a grip.

Hernán Andrés de la Barra Ortiz

Principal Investigator and Clinical Professor

Quiropraxia y Equilibrio

EMP levels will be measured at ICU admission in subjects with physician-suspected sepsis. For each subject, the final diagnosis of sepsis or non-sepsis critical illness will be adjudicated using standard criteria. The subjects without sepsis will form the Test Cohort.

EMP levels will be measured at ICU admission in subjects with physician-suspected sepsis. For each subject, the final diagnosis of sepsis or non-sepsis critical illness will be adjudicated using standard criteria.The subjects determined to have sepsis will serve as the Validation Cohort .

Systemic Inflammatory Response Syndrome

Weill Cornell Medical College

Hamad Medical Corporation

Endothelial Microparticles as a Biomarker for Diagnosis and Prognosis in Early Sepsis

To evaluate the hypothesis that EMP level is a predictive biomarker for the diagnosis of sepsis. For the primary objective, a prospective, cross-sectional, case control design will be utilized. EMP levels will be measured at ICU admission in subjects with physician-suspected sepsis. For each subject, the final diagnosis of sepsis or non-sepsis critical illness will be adjudicated using standard criteria, and the subjects determined to have sepsis will serve as the cases while those subjects without sepsis will form the control group.

To evaluate the hypothesis that EMP level is a predictive biomarker for mortality in sepsis. For the secondary objective, EMP levels will be measured on admission and daily for the first 5 ICU days or until the subject dies or leaves the ICU. While data will be collected prospectively on all subjects, the cohort for analysis for this objective will include only those subjects with a validated diagnosis of sepsis. In these subjects, 30-day mortality will be ascertained, and EMP levels correlated with mortality to determine the utility of EMPs as a biomarker for mortality risk in sepsis.

hemoglobinuria/ödem

Cold and Isometric Strength

Endothelial Microparticles as a Biomarker for Diagnosis and Prognosis in Early Sepsis

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