inosine/nekroz

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Cytoprotective effects of adenosine and inosine in an in vitro model of acute tubular necrosis.

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OBJECTIVE We have established an in vitro model of acute tubular necrosis in rat kidney tubular cells, using combined oxygen-glucose deprivation (COGD) and screened a library of 1280 pharmacologically active compounds for cytoprotective effects. METHODS We used in vitro cell-based, high throughput,

Protective effect of inosine on adrenaline-induced myocardial necrosis.

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The influence of inosine (200 and 400 mg/kg i.p.) on adrenaline-induced myocardial necrosis in rats was studied. Adrenaline in a single dose (1 and 2 mg/kg s.c.) produced heart cell necrosis estimated by plasma activities of CPK-MB, CPK, blood lactates concentration and histopathological

Extracellular inosine participates in tumor necrosis factor-alpha induced nitric oxide production in cultured Sertoli cells.

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Recent reports have described purinergic modulation of tumor necrosis factor-alpha (TNF-alpha) signaling in neutrophils and astrocytes. In Sertoli cells, both TNF-R1 and TNF-R2 TNF-alpha receptors are present and this cytokine modulates many functions of these cells related to the maintenance of

Inosine-mediated modulation of RNA sensing by Toll-like receptor 7 (TLR7) and TLR8.

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RNA-specific adenosine deaminase (ADAR)-mediated adenosine-to-inosine (A-to-I) editing is a critical arm of the antiviral response. However, mechanistic insights into how A-to-I RNA editing affects viral infection are lacking. We posited that inosine incorporation into RNA facilitates sensing of

Inhibitors of infectious pancreatic necrosis virus (IPNV) replication.

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In attempts to detect inhibitors of infectious pancreatic necrosis virus (IPNV) replication, we have evaluated, by an IPNV plaque inhibition assay, a group of compounds that have broad spectrum antiviral activity for both single- and double-stranded RNA viruses. The inosine monophosphate

Effects of inosine 5'-monophosphate supplementation in high fishmeal and high soybean diets on growth, immune-related gene expression in gibel carp (Carassius auratus gibelio var. CAS Ⅲ), and its challenge against Aeromonas hydrophila infection.

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The present study was conducted to evaluate dietary inosine 5'-monophosphate (5'-IMP) on growth, immune genes expression and disease resistance against Aeromonas hydrophila in juvenile gibel carp (Carassius auratus gibelio var. CAS Ⅲ) (initial body weight: 7.48 g). Six diets were formulated

[Amelioration of inflammatory reaction in patients with severe sepsis with inosine].

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OBJECTIVE To evaluate the therapeutic effect of inosine in patients with severe sepsis. METHODS A prospective study was conducted. Eighty-five severe sepsis patients hospitalized in intensive care unit (ICU) from March 2011 to August 2012 were included and randomized into three groups: 25 cases as

Inosine stimulates chemotaxis, Ca2+-transients and actin polymerization in immature human dendritic cells via a pertussis toxin-sensitive mechanism independent of adenosine receptors.

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Inosine is an endogenous purine nucleoside, which is formed by adenosine deaminidase during adenosine breakdown and is released into the extracellular space from the sympathetic nervous system or injured cells. Here, we studied the biological activity of inosine on human dendritic cells (DC), which

Adenosine modulation of tumor necrosis factor-alpha-induced neutrophil activation.

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We hypothesized that adenosine, known to be release from inflammatory sites, could lessen the potentially damaging activity of neutrophils (PMN) primed by tumor necrosis factor-alpha (TNF alpha) at sites of infection. We investigated the effect of adenosine on PMN primed with cell-free medium from

Widespread inosine-containing mRNA in lymphocytes regulated by ADAR1 in response to inflammation.

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Adenosine-to-inosine (A-to-I) RNA editing is a post-transcriptional modification of pre-mRNA catalysed by an RNA-specific adenosine deaminase (ADAR). A-to-I RNA editing has been previously reported in the pre-mRNAs of brain glutamate and serotonin receptors and in lung tissue during inflammation.

Resistance to nitric oxide-induced necrosis in heme oxygenase-1 overexpressing pulmonary epithelial cells associated with decreased lipid peroxidation.

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Increased expression of heme oxygenase-1 (HO-1) increases NO resistance in several cell types, although the biochemical mechanism for this protection is unknown. To address this issue, we have measured different molecular markers of nitrosative stress in three stably transfected cell lines derived

Protective effect of inosine against adrenaline toxicity in rats.

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The effect of inosine (200 mg/kg ip) injected 30 and 10 min before adrenaline (AD) administration to rats was studied. AD in the single dose (2 mg/kg sc) evoked heart necrosis evidenced by plasma activities of CPK-MB, CPK, blood lactates concentrations and histopathological examination. Inosine

Inosine and guanosine preserve neuronal and glial cell viability in mouse spinal cord cultures during chemical hypoxia.

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Murine spinal cord primary mixed cultures were treated with the respiratory inhibitor, rotenone, to mimic hypoxic conditions. Under these conditions neurons rapidly underwent oncosis (necrosis) with a complete loss in viability occurring within 260 min; however, astrocytes, which accounted for most

Inhibitory effect of mycophenolic acid on the replication of infectious pancreatic necrosis virus and viral hemorrhagic septicemia virus.

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Infectious pancreatic necrosis virus (IPNV) and viral hemorrhagic septicemia virus (VHSV) remain two of the most important pathogens of farmed trout worldwide. Mycophenolic acid (MPA) is an inhibitor of cellular inosine monophosphate dehydrogenase (IMPDH), an enzyme that catalyzes an essential step

Cloning and expression of Malabar grouper (Epinephelus malabaricus) ADAR1 gene in response to immune stimulants and nervous necrosis virus.

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ADARs are RNA editing catalysts that bind double-stranded RNA and convert adenosine to inosine, a process that can lead to destabilization of dsRNA structures and suppression of mRNA translation. In mammals, ADAR1 genes are involved in various cellular pathways, including interferon (IFN)-mediated

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