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lactone/enflamasyon

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Sayfa 1 itibaren 43 Sonuçlar

Use of sesquiterpene lactones for treatment of severe inflammatory disorders

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This invention pertains to sesquiterpene lactones and sesquiterpene lactone-containing plant extracts and preparations for pharmaceutical uses, particularly the use of sesquiterpene lactones for the treatment of severe inflammatory disorders, for example, sepsis, septic shock, or septicemia. A large

Antiinflammatory lactones

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The present invention relates to anti-inflammatory lactones. In one aspect the present invention provides a compound of formula ##STR00002## such as a compound of formula ##STR00003## wherein R is hydroxy or amino. A compound of formula I includes a compound of formula I'. Preferably in a compound

Synthetic lactone formulations and methods of use

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FIELD OF THE INVENTION The present inventions are generally in the fields of pharmaceutically active lactones, their pharmaceutical formulations, and method of use thereof, and methods for the synthetic preparation of chemically functionalized lactones useful therefor as anticancer, antiinfective

Synthetic lactone formulations and method of use

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The present inventions are generally in the fields of pharmaceutically active lactones, their pharmaceutical formulations, and method of use thereof, and methods for the synthetic preparation of chemically functionalized lactones useful therefor as anticancer, antiinfective and anti-inflammatory

Synthetic anti-inflammatory derivatives of manoalide

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BACKGROUND OF THE INVENTION Concurrently filed U.S. patent application Ser. No. 519,852, now U.S. Pat. No. 4,447,445 relates to the discovery of the analgesic and anti-inflammatory properties of manoalide. The present invention relates to synthetic analogs of manoalide which have been shown to have

Regioselective synthesis of 1,5-diaryl pyrazole anti-inflammatory agents

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BACKGROUND OF THE INVENTION The standard synthesis for pyrazoles involves the reaction of a .beta..epsilon..tau..alpha.-dicarbonyl compound with a hydrazine under mild conditions. See A. R. Katritzky in "The Principles of Heterocyclic Chemistry", Academic Press, New York (1968) at page 139. When the

Combinations of sesquiterpene lactones and ditepene triepoxide lactones for synergistic inhibition of cyclooxygenase-2

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FIELD OF THE INVENTION The present invention relates generally to a composition exhibiting synergistic inhibition of the expression and/or activity of inducible cyclooxygenase-2 (COX-2). More particularly, the composition comprises a combination of a diterpene triepoxide lactone species and a

Combinations of diterpene triepoxide lactones and ditepene lactones or triterpenes for synergistic inhibition of cyclooxygenase-2

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FIELD OF THE INVENTION The present invention relates generally to a composition exhibiting synergistic inhibition of the expression and/or activity of inducible cyclooxygenase-2 (COX-2). More particularly, the composition comprises, as a first component, a diterpene triepoxide lactone species and,

Compositions that treat or inhibit pathological conditions associated with inflammatory response

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BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates generally to compositions that can be used to treat or inhibit pathological conditions associated with tissue-specific activation of inflammation and/or NF.kappa.B, to methods of modulating inflammation, including in

Synergistic compositions that treat or inhibit pathological conditions associated with inflammatory response

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BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates generally to synergistic compositions that treat or inhibit pathological conditions associated with tissue-specific activation of inflammation and to methods of modulating inflammation in cells. More specifically,

Synergistic compositions that treat or inhibit pathological conditions associated with inflammatory response

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BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates generally to synergistic compositions that treat or inhibit pathological conditions associated with tissue-specific activation of inflammation and to methods of modulating inflammation in cells. More specifically,

Compositions that treat or inhibit pathological conditions associated with inflammatory response

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BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates generally to compositions that can be used to treat or inhibit pathological conditions associated with tissue-specific activation of inflammation and/or NF.kappa.B, to methods of modulating inflammation, including in

Compositions that treat or inhibit pathological conditions associated with inflammatory response

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BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates generally to compositions that can be used to treat or inhibit pathological conditions associated with tissue-specific activation of inflammation and/or NF.kappa.B, to methods of modulating inflammation, including in

Compositions that treat or inhibit pathological conditions associated with inflammatory response

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BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates generally to compositions that can be used to treat or inhibit pathological conditions associated with tissue-specific activation of inflammation and/or NF.kappa.B, to methods of modulating inflammation, including in

Synergistic compositions that treat or inhibit pathological conditions associated with inflammatory response

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Giriş yapmak kayıt olmak
BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates generally to synergistic compositions that treat or inhibit pathological conditions associated with tissue-specific activation of inflammation and to methods of modulating inflammation in cells. More specifically,
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