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Breast cancer: Lesser-known facets and hypotheses.

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Breast cancer is the most common cancer in females. The deteriorating environment, and lifestyle flaws are raising the frequency of this cancer. Existing therapies are not universally-effective, and they cause side effects, relapses, and high mortality rate. Alternative medications may be milder,

A lesser evil: prophylactic mastectomy for women at high risk for breast cancer.

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[Isolated fracture of the lesser trochanter-What age-related differences are important?]

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Isolated fractures of the lesser trochanter are very rare injuries. This case report describes the age-related differences based on two cases. A 13-year-old girl suffered an avulsion fracture of the lesser trochanter while sprinting. The patient received conservative treatment with pain-adapted

Do socially deprived urban areas have lesser supplies of cancer care services?

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OBJECTIVE Area social deprivation is associated with unfavorable health outcomes of residents across the full clinical course of cancer from the stage at diagnosis through survival. We sought to determine whether area social factors are associated with the area health care supply. METHODS We studied

Luteolin as a glycolysis inhibitor offers superior efficacy and lesser toxicity of doxorubicin in breast cancer cells.

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Luteolin (Lu) exhibits a wide spectrum of anti-tumor activities, the present study was to observe whether Lu can sensitize breast cancer cells to doxorubicin (Dox) and to explain the basis underlying this phenomenon. In vitro, Lu at dose less than 100 microM had only slight effect on cells growth

Polygenic risk score for the prediction of breast cancer is related to lesser terminal duct lobular unit involution of the breast

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Terminal duct lobular units (TDLUs) are the predominant anatomical structures where breast cancers originate. Having lesser degrees of age-related TDLU involution, measured as higher TDLUs counts or more epithelial TDLU substructures (acini), is related to increased breast cancer risk among women

Discovery of lesser known flavones as inhibitors of NF-κB signaling in MDA-MB-231 breast cancer cells--A SAR study.

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Seventeen flavonoids with different substitutions were evaluated for inhibition of nuclear factor-κB (NF-κB) signaling in the invasive breast cancer cell line MDA-MB-231. They were screened using an engineered MDA-MB-231 cell line reporting NF-κB activation. The modulation of expression of two NF-κB

Short tangential arcs in VMAT based breast and chest wall radiotherapy lead to conformity of the breast dose with lesser cardiac and lung doses: a prospective study of breast conservation and mastectomy patients.

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Volumetric modulated arc therapy (VMAT) is modern rotational intensity modulated therapy used for treatment of several sites. The study aimed to analyze partial tangential arc VMAT treatment planning and delivery, including analyzing the cardiac and contralateral breast doses resulting from this

Intra nuclear estrogen receptor status and its clinicopathological correlation in breast cancer patients.

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Intranuclear estrogen receptor (ERn) content of breast cancer tissue is thought to be more closely related to prognosis, and response to hormone treatment, as compared to conventional cytosolic estrogen receptor (REc). ERn and ERc levels in primary breast carcinoma tissue were assayed by ER-Enzyme

The Histone Deacetylase Inhibitor JAHA Down-Regulates pERK and Global DNA Methylation in MDA-MB231 Breast Cancer Cells.

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The histone deacetylase inhibitor N¹-(ferrocenyl)-N⁸-hydroxyoctanediamide (JAHA) down-regulates extracellular-signal-regulated kinase (ERK) and its activated form in triple-negative MDA-MB231 breast cancer cells after 18 h and up to 30 h of treatment, and to a lesser extent AKT and phospho-AKT after

Principles of surgical management of breast cancer.

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Until recently surgical ablation was the primary treatment of choice for operable breast cancers. Increasingly, this position has been challenged by concepts of lesser surgical procedures coupled with radiotherapy. The trend of recurrence rates suggests that wide local excision of the primary tumor

[Development of a therapeutic strategy and role of surgery in breast cancer].

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The evolution of therapeutic strategy and the role of surgery in breast cancer. Loco-regional control of breast cancer is achieved with lesser surgical mutilation. Quality of results is however dependent of the stage of the disease more than of therapeutic modalities.

Cytotoxic T lymphocyte antigen-4 promoter variants in breast cancer.

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CTLA4 is a coinhibitory molecule expressed mainly on activated T lymphocytes. To test the putative involvement of CTLA-4 in inhibitory state of immunity to breast cancer, we genotyped 283 patients and 245 healthy control subjects for -1722 T/C, -1661 A/G, and -318 C/T single nucleotide polymorphisms

The combination of FDG PET and dynamic contrast-enhanced MRI improves the prediction of disease-free survival in patients with advanced breast cancer after the first cycle of neoadjuvant chemotherapy.

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OBJECTIVE The aim of this study was to investigate the potential of FDG PET/CT and MRI in predicting disease-free survival (DFS) after neoadjuvant chemotherapy (NAC) and surgery in patients with advanced breast cancer. METHODS The analysis included 54 women with advanced breast cancer. All patients

Nomegestrol acetate/estradiol hormonal oral contraceptive and breast cancer risk.

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Combined hormonal contraceptives (CHCs) contain estrogen and progestin, which can stimulate estrogen-sensitive and/or progesterone-sensitive breast cancer growth. Until recently, ethinylestradiol had been almost the only estrogen used for decades, and its dose has been greatly reduced over time. The

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