Only the group of participants with primary Raynaud's phenomenon (Raynaud's disease) is also scheduled for this intervention, the 123I-MIBG.

Examination of vibration perception threshold in fingertips, thermography, Ewing's test, tilt table test, blood samples.

Raynaud Disease

Raynaud Phenomenon

Hand and Arm Vibration Syndrome

Diabetes Mellitus

Parkinson Disease

Glaucoma

Autonomic Neuropathy

Autonomic Imbalance

Vibration perception threshold is examined for 7 different frequences. All fingers are examined except for the thumbs.

Examination of vibration perception threshold in fingertips

A battery of tests invented to diagnose the cardiac autonomic neuropathy in diabetics. Heart rate and blood pressure are measured during Valsalva maneuver, deep breathing, active standing and prolonged handgrip.

Ewing's tests

Blood pressure and heart rate are measured continuously while the participant is brought to a 60 degree position and held there for 15 minutes.

Tilt table test

An infrared thermographic camera is applied to record temperature of the fingers of the participant before and after cooling in 10 degree water for 1 min.

Thermography

123I-MIBG is injected into a vein, and an early and a late scan is performed. Regions Of Interest are selected for the heart and mediastinum, and the ratio as well as well as the Washout Rate can be determined. MIBG is a noradrenaline analogue and the examination is performed to visualize a potential imbalance of the autonomic nervous system of the heart.

123I-MIBG

The blood samples will be assayed for hemoglobin, long-term blood sugar, C-reactive protein, sodium, potassium, magnesium, albumin, TSH, vitamin B and D, and ionized calcium.
Patients with suspected Raynaud's disease will be tested for anti-nuclear antibodies (ANA) to screen for underlying rheumatic illness.
Blood samples will also be drawn during tilt table testing and assayed for plasma catecholamines.

Blood samples

Department of Clinical Physiology and Nuclear Medicine, Herlev Hospital

Investigation of the Rewarming og the Fingers After Cooling and the Autonomic Nervous System in Raynaud's Phenomenon

RaynAUT - Thermography and the Autonomic Nervous System in Raynaud's Phenomenon - Investigation of the Autonomic Nervous System in Patients With Raynaud's Phenomenon, Glaucoma, and Autonomic Neuropathy.

Determination of which variables are able to distinguish the participants with Raynaud's phenomenon from the healthy participants.
Temperature (degrees celsius), time (minutes), degrees/min, acceleration of temperature change (degrees/min^2), recovery index (percent).
All measurements will be evaluated in terms of ability to diagnose Raynaud's phenomenon. Finally, the most prominent variables are aggregated to determine whether or not the participant has Raynaud's phenomenon or not.

Determination of HRV from participants with Raynaud's phenomenon, with diagnosed autonomic neuropathy, and healthy participants. All measurements will be aggregated to determine whether HRV differs among the different groups of participants.

Lotte Lindberg

Principal investigator

Herlev Hospital

All Groups

Sex/Gender, Customized

Region of Enrollment

Adverse Events assessed in accordance with CTCAE (NCI Common Terminology Criteria for Adverse Events) Version 3.0.

Number of Participants Experiencing Serious Adverse Events Including But Not Limited to Hospitalizations, Deaths Related to Treatment, or Other Incapacitating Conditions.

Response and progression will be evaluated in this study using measurements from the MRI/CT scans. Measurements will be made of the image slice with the largest cross sectional area. Two orthogonal measures will be made to determine maximal AP and lateral dimensions. Progression of disease will be defined as a greater than 25% increase of largest cross sectional area by two orthogonal measurements, taking as reference the smallest sum recorded since the treatment started or the appearance of one or more new lesions.

Hydroxyurea: Hydroxyurea inhibits DNA synthesis by inhibition of ribonucleotide diphosphate reductase and is a well-known drug used for the treatment of a number of tumor types including head and neck tumors and chronic myelogenous leukemia. It has also been used as an adjuvant for antiretroviral treatment for patients with HIV and as a treatment for polycythemia vera, essential thrombocythemia and sickle cell disease.
Verapamil: Verapamil is another commonly used medication. It is used for the treatment of angina, hypertension, supraventricular arrhythmias, and migraine prophylaxis. Dosing with standard verapamil is 80-120 mg pox three times a day but the sustained release form can be given 120-480mg once or twice each day.

All Participants

Median Progression-free Survival Rates of the Treatment Population.

Overall Study

Dr. Randy Jensen

Cancer

Brain Cancer

Meningioma

Hydroxyurea inhibits DNA synthesis by inhibition of ribonucleotide diphosphate reductase and is a well-known drug used for the treatment of a number of tumor types including head and neck tumors and chronic myelogenous leukemia. It has also been used as an adjuvant for antiretroviral treatment for patients with HIV and as a treatment for polycythemia vera, essential thrombocythemia and sickle cell disease.

Hydroxyurea

Verapamil is another commonly used medication. It is used for the treatment of angina, hypertension, supraventricular arrhythmias, and migraine prophylaxis. Dosing with standard verapamil is 80-120 mg pox three times a day but the sustained release form can be given 120-480mg once or twice each day.

Verapamil

Huntsman Cancer Institute

Combination of Hydroxyurea and Verapamil for Refractory Meningiomas

University of Utah

1. Inactive Placebo Pill

2. Active Medication

Total

Sex: Female, Male

Change in food intake from baseline to week 3.

migraine disorders/albümin

Investigation of the Rewarming og the Fingers After Cooling and the Autonomic Nervous System in Raynaud's Phenomenon

Combination of Hydroxyurea and Verapamil for Refractory Meningiomas

Effects of Divalproex Sodium on Food Intake, Energy Expenditure, and Posture Allocation

Bilim tarafından desteklenen en eksiksiz şifalı otlar veritabanı