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COMPARATIVE STUDIES IN ROUS SARCOMA WITH VIRUS, TUMOR CELLS, AND CHICK EMBRYO CELLS TRANSFORMED IN VITRO BY VIRUS : I. PRODUCTION OF MUCOPOLYSACCHARIDES.

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The chick embryo fibroblast infected by Rous sarcoma virus in vitro acquires the capacity to produce the acid mucopolysaccharides which are found in the tumors caused by this virus and which are also produced by tumor cells in vitro. The transformed cell acquires synthetic as well as morphologic,

Detection of acid mucopolysaccharides in human brain tumors by histochemical methods.

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Acid mucopolysaccharides (glycosaminoglycans) are identified by histochemical methods in biopsies of 107 human brain tumors. Isomorphous oligodendrogliomas and astrocytomas stained with alcian blue show marked, weblike, or diffuse distribution and concentration of acid mucopolysaccharides.

Mucopolysaccharides in peripheral leucocytes of cancer patients.

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The presence of mucopolysaccharides (MPS) in leucocytes of peripheral blood of 19 cancer patients, 13 patients with pulmonary tuberculosis and 14 normal controls, was studied histochemically. MPS was revealed in different proportions in polynuclears and mononuclears. According to the staining

Acidic mucopolysaccharide from Holothuria leucospilota has antitumor effect by inhibiting angiogenesis and tumor cell invasion in vivo and in vitro.

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Acidic mucopolysaccharide from Holothuria Leucospilota (HS) may affect some steps in metastasis cascade. In vitro, HS inhibited the growth of B16F10 cells and proliferation of VEGF-induced HUVEC dose-dependently compared to the control, VEGF-induced capillary-like tube networks and the numbers of

[Antitumor effect of Stichopus japonicus acidic mucopolysaccharide combined with fluorouracil in mice bearing neoplasia of H22 hepatoma cells].

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OBJECTIVE To observe the antitumor effect of Stihopus japonicus acidic mucopolysaccharide combined with fluorouracil in mice bearing neoplasia of H22 hepatoma cells, and study the mechanism. METHODS Inoculate the H22 liver cancer cells in the right forelimbs axillary region subcutaneous of 50

[ACTION OF MUCOPOLYSACCHARIDES FROM NORMAL AND TUMOR TISSUE ON THE GROWTH OF SARCOMA 180].

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[Interrelations of zymosan, properdin & tumors. IV. Behavior of mucopolysaccharides in the blood in benzopyrene sarcoma-bearing rats].

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[Tumour induction by methylnitrosourea in clawed frogs (Xenopus laevis) (author's transl)].

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15 clawed frogs were bathed 12 to 17 times in solutions of 2 mg methylnitrosourea, dissolved in 1000 ml destilled water. 7 frogs developed tumours 8 to 22 months after starting the experiments. Another frog died of polycystic kidneys. The tumours were adenocarcinomas of the kidneys, sarcomas and a

Cytopathology of uncommon malignant renal neoplasms in the pediatric age group.

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Malignant renal neoplasms are common solid tumors in pediatric oncology practice. These include the common Wilms' tumor/nephroblastoma and the uncommon neoplasms such as clear-cell sarcoma of the kidney (CCSK), rhabdoid tumor, renal-cell carcinoma, and others. The aim of this study was to describe

N-[18F]fluoroacetyl-D-glucosamine: a potential agent for cancer diagnosis.

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Positron labeled substrates such as sugars, amino acids, and nucleosides have been investigated for the in-vivo evaluation of biochemical processes in cancerous tissue. Hexosamines are obligatory structural components of many biologically important macromolecules, including membrane glycoproteins

Biodistribution of 95Nb and 182Ta in tumor-bearing animals and mechanisms for accumulation in tumor and liver.

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The biodistribution and binding substances of 95Nb and 182Ta were investigated and compared with other nuclides using tumor-bearing rats and mice. Retention values of 95Nb in tumor tissue were greater than those for 67Ga-citrate, while those for 182Ta were similar to those for 67Ga. The values for

Radioactive ruthenium red accumulation by tumors: a potential scanning agent.

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The distribution of 103-Ru-Ruthenium red in tumour bearing animals indicates that Ruthenium red labelled with radioruthenium shows the characteristics of a tumour scanning agent. Its accumulation seems to be related to its specific binding to mucopolysaccharides. In addition, this radiocompound

[Hyaluronidase in cytostatic therapy of ENT tumors].

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In 27 patients with squamous cell carcinomas of the head and neck region hyaluronidase was added to cytostatic chemotherapy, in part of them from the beginning and in part after development of chemoresistance. We administered either ampoules containing 750 i. u. of Permease in a dosage between 7,500

Enhancement of oxidative response and cytokine production by yam mucopolysaccharide in murine peritoneal macrophage.

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Yam (Dioscorea batatas) mucopolysaccharide (YMP) was examined for the ability to induce secretory and cellular responses in murine peritoneal macrophages. When macrophages were treated with various doses (10-100 microg/ml) of YMP for 48 h, a significant cytotoxicity against B 16 cells was observed.

The research progress of antitumorous effectiveness of Stichopus japonicus acid mucopolysaccharide in north of China.

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The sea cucumbers growing in the estuary of the Pohai of northern China are called Stichopus japonicus and are the orthodox holothurians in traditional Chinese medicine. There are multiple biological active ingredients in S. japonicus, and S. japonicus acid mucopolysaccharide (SJAMP) is one of the

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