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mumps/protease

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Conversion of nonfusing mumps virus infections to fusing infections by selective proteolysis of the HN glycoprotein.

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Mumps virus strains differ in their ability to induce cell fusion following an infection: strains with active neuraminidase (NANase) fail to cause cell fusion, while strains with less active NANase cause cell fusion. When chymotrypsin is added to infected cells, cell fusion is amplified in a

Cloning and secreted expression of the extracellular domain of the mumps virus fusion protein in Pichia pastoris.

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The extracellular globular domain of the mumps virus fusion (F) protein (amino-acids 28-481) has been overexpressed from GS115 his4 Pichia pastoris cells following the generation of a recombinant clone. The heterologous protein was directed for secreted expression by in-frame cloning with the S.

Lysosome-associated membrane proteins support the furin-mediated processing of the mumps virus fusion protein.

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Mumps virus (MuV), an enveloped RNA virus of the Paramyxoviridae family and the causative agent of mumps, affects the salivary glands and other glandular tissues as well as the central nervous system. The virus enters the cell by inducing the fusion of its envelope with the plasma membrane of

AR-12 Inhibits Multiple Chaperones Concomitant With Stimulating Autophagosome Formation Collectively Preventing Virus Replication.

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We have recently demonstrated that AR-12 (OSU-03012) reduces the function and ATPase activities of multiple HSP90 and HSP70 family chaperones. Combined knock down of chaperones or AR-12 treatment acted to reduce the expression of virus receptors and essential glucosidase proteins. Combined knock

SARS-CoV-2 infection, COVID-19 pathogenesis, and exposure to air pollution: What is the connection?

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Exposure to air pollutants has been previously associated with respiratory viral infections, including influenza, measles, mumps, rhinovirus, and respiratory syncytial virus. Epidemiological studies have also suggested that air pollution exposure is associated with increased cases of SARS-CoV-2
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