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octanol/ateş

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Effects of antioxidants on X-ray- or hyperthermia-induced apoptosis in human lymphoma U937 cells.

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Hydroxyl radicals (.OH) and superoxide anion radicals (O2.-) are known to play cardinal roles in cell killing and various types of cell damage. In order to elucidate the mechanism of the involvement of both free radicals on apoptosis, the correlation between anti-apoptotic effects and free radical

Correlation between the n-alkanols-induced sensitization of erythrocytes to hyperthermia and the fluidization of their membrane.

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It was reported recently that the thermohaemolysis of mammalian erythrocytes is related to a thermo-induced membrane event of permeability barrier impairment in which the inactivation of membrane proteins is implicated. Here, the influence of different n-alkanols, methanol to octanol, on the onset

Use of N-sigma-dansyl-L-lysine and flow cytometry to identify heat-killed mammalian cells.

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We have employed the nontoxic fluorescent membrane probe, N-sigma-dansyl-L-lysine (DL) to study the effect of mild (45.5 degrees C) heat shock on a variety of mammalian cell lines. It has been previously proposed by Humphries and Lovejoy (1983) that DL selectively partitions into (and diffuses

Quantitative structure-activity relationships in the 2,4,5-ring substituted phenylisopropylamines.

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The potency of a series of 2,4,5-ring substituted phenylisopropylamines was examined using the rabbit hyperthermia assay. An excellent correlation (r = 0.99) was found between the rabbit hyperthermic and human psychotomimetic potencies. In the hyperthermic model, the

Predictability of the clinical potency of NSAIDs from the preclinical pharmacodynamics in rats.

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OBJECTIVE Relevance of the preclinical pharmacodynamic, toxicity and pharmacokinetic parameters predicting the clinical potency of nonsteroidal antiinflammatory drugs (NSAIDs) was evaluated. METHODS Data for oral potencies of 24 NSAIDs in rats were collected from the literature and from New Drug
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