Osteoporosis / protease

Cyanamides useful as reversible inhibitors of cysteine proteases

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FIELD OF THE INVENTION This invention relates to cyanamide compounds useful as reversible inhibitors of the cysteine proteases cathepsins S, K, F, L and B. Certain embodiments described are preferable for inhibition of cathepsin K. The compounds are therefore useful in the treatment of cysteine

Compounds and compositions as protease inhibitors

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THE INVENTION This application relates to compounds and compositions for treating diseases associated with cysteine protease activity, particularly diseases associated with activity of cathepsins B, K, L or S. DESCRIPTION OF THE FIELD Cysteine proteases represent a class of peptidases characterized

Cathespin cysteine protease inhibitors

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BACKGROUND OF THE INVENTION A variety of disorders in humans and other mammals involve or are associated with abnormal bone resorption. Such disorders include, but are not limited to, osteoporosis, glucocorticoid induced osteoporosis, Paget's disease, abnormally increased bone turnover, periodontal

Regulation of human eosinophil serine protease 1-like enzyme

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TECHNICAL FIELD OF THE INVENTION The invention relates to the regulation of a human eosinophil serine protease 1-like enzyme. BACKGROUND OF THE INVENTION Serine proteases are members of a family of proteolytic enzymes characterized by the presence of a cardinal serine in the catalytic site. They

Protease inhibitors

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FIELD OF THE INVENTION This invention relates in general to bis-aminomethyl carbonyl protease inhibitors, particularly such inhibitors of cysteine and serine proteases, more particularly compounds which inhibit cysteine proteases, even more particularly compounds which inhibit cysteine proteases of

Protease inhibitors

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FIELD OF THE INVENTION This invention relates in general to C.sub.1-6alkyl-4-amino-azepan-3-one protease inhibitors, particularly such inhibitors of cysteine and serine proteases, more particularly compounds which inhibit cysteine proteases, even more particularly compounds which inhibit cysteine

Protease inhibitors

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This is a 371 of International Application PCT/US01/07094, filed Mar. 7, 2001, which claims benefit from the following U.S. Provisional Applications: 60/191,000 filed Mar. 21, 2000; 60/206,341 filed May 23, 2000; 60/211,759 filed Jun. 14, 2000; and 60/217,445 filed Jul. 10, 2000. FIELD OF THE

Protease inhibitors

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FIELD OF THE INVENTION This invention relates in general to hydrazidyl, bis-hydrazidyl and bis-aminomethyl carbonyl protease inhibitors, particularly such inhibitors of cysteine and serine proteases, more particularly compounds which inhibit cysteine proteases, even more particularly compounds which

Protease inhibitors

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FIELD OF THE INVENTION This invention relates in general to hydrazidyl, bis-hydrazidyl and bis-aminomethyl carbonyl protease inhibitors, particularly such inhibitors of cysteine and serine proteases, more particularly compounds which inhibit cysteine proteases, even more particularly compounds which

Protease inhibitors

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FIELD OF THE INVENTION This invention relates in general to hydrazidyl, bis-hydrazidyl and bis-aminomethyl carbonyl protease inhibitors, particularly such inhibitors of cysteine and serine proteases, more particularly compounds which inhibit cysteine proteases, even more particularly compounds which

Protease inhibitors

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FIELD OF THE INVENTION This invention relates in general to hydrazidyl, bis-hydrazidyl and bis-aminomethyl carbonyl protease inhibitors, particularly such inhibitors of cysteine and serine proteases, more particularly compounds which inhibit cysteine proteases, even more particularly compounds which

Cathepsin cysteine protease inhibitors

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BACKGROUND OF THE INVENTION A variety of disorders in humans and other mammals involve or are associated with abnormal bone resorption. Such disorders include, but are not limited to, osteoporosis, glucocorticoid induced osteoporosis, Paget's disease, abnormally increased bone turnover, periodontal

Cathepsin cysteine protease inhibitors

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BACKGROUND OF THE INVENTION A variety of disorders in humans and other mammals involve or are associated with abnormal bone resorption. Such disorders include, but are not limited to, osteoporosis, glucocorticoid induced osteoporosis, Paget's disease, abnormally increased bone turnover, periodontal

Cathepsin cysteine protease inhibitors

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BACKGROUND OF THE INVENTION A variety of disorders in humans and other mammals involve or are associated with abnormal bone resorption. Such disorders include, but are not limited to, osteoporosis, glucocorticoid induced osteoporosis, Paget's disease, abnormally increased bone turnover, periodontal

Cathepsin cysteine protease inhibitors

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BACKGROUND OF THE INVENTION A variety of disorders in humans and other mammals involve or are associated with abnormal bone resorption. Such disorders include, but are not limited to, osteoporosis, glucocorticoid induced osteoporosis, Paget's disease, abnormally increased bone turnover, periodontal

osteoporosis/protease

Cyanamides useful as reversible inhibitors of cysteine proteases

Compounds and compositions as protease inhibitors

Cathespin cysteine protease inhibitors

Regulation of human eosinophil serine protease 1-like enzyme

Protease inhibitors

Protease inhibitors

Protease inhibitors

Protease inhibitors

Protease inhibitors

Protease inhibitors

Protease inhibitors

Cathepsin cysteine protease inhibitors

Cathepsin cysteine protease inhibitors

Cathepsin cysteine protease inhibitors

Cathepsin cysteine protease inhibitors

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