6 months treatment with the medication Ramipril

Peripheral Arterial Disease

Ramipril therapy will start at 2.5mg/day for 1 week. Then 5mg/day for 1 week and will be increased to 10mg/day by the third week. The patients will stay on Ramipril 10mg/day for 22 weeks.

Ramipril

VA Medical Center

Ramipril Treatment of Claudication

Ramipril Treatment of Claudication: Oxidative Damage and Muscle Fibrosis

Maximum walking distance in meters per Gardner protocol

Maximum Distance in meters the patient can walk in 6 minutes on a flat, hard surface

The distance in meters the patient can walk before he experiences claudication pain, per Gardner protocol

Ratio of the blood pressure at the level of the ankle to the blood pressure at the level of the arm

Myofiber content of HNE adducts and protein carbonyls

Area in square microns, measured by immunofluorescence microscopy

Measured as ratio of major axis in microns to minor axis in microns

Measured as the ratio of myofiber area in square microns to the area of a fitted convex hull in square microns

Measured as the sum of the products of mean pixel intensity (in gray scale units) and area (in square microns) of each TGF-β1 labeled event divided by the total area (in square microns) of the tissue sample analyzed. Measured by immunofluorescence microscopy.

Measured as the area-weighted mean pixel intensity (in gray scale units) of all the collagen labeled events per tissue sample. Measured by bright-field microscopy.

Measured in microns by immunofluorescence microscopy of vessels labeled for collagen.

Number of capillaries per unit area (in square microns) of the tissue sample analyzed.

Iraklis I Pipinos, MD

Professor of Surgery

University of Nebraska

Healthy

Biocárdios - Instituto de Cardiologia

University of Campinas

Brasília Study on Healthy Aging

Sudden cardiac death (unrelated to trauma, unexpected, and occurring in less than six hours after onset of symptoms), fatal MI (any death preceded by MI) or non-fatal MI.

Andrei Carvalho Sposito

M.D., Ph.D.

University of Campinas, Brazil

Instituto de Cardiologia Biocardios

University of Brasilia

Patients will be given 100mg of diclophenac sodium two hours prior to colonoscopy.

Patients will be given placebo tablets of same appearance as the intervention.

Anemia

Patients will be given 100mg p.o. diclophenac sodium tablets

diclophenac sodium

Inactive pill manufactured to mimic diclofenac tablet

peripheral arterial disease/phosphatase

Ramipril Treatment of Claudication

Brasília Study on Healthy Aging

Diclophenac Versus Placebo for Pain Control in Diagnostic Colonoscopy

Bilim tarafından desteklenen en eksiksiz şifalı otlar veritabanı