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Grape seed extract effects in brain after hypobaric hypoxia.

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Hypoxia induces a wide range of deleterious effects at the cellular level due to an increased production of reactive oxygen species (ROS). Polyphenols from grape seeds, which are potent antioxidants might protect the brain against oxidative stress produced by hypobaric hypoxia. The brain effects of

[Effect and mechanism of methyl protodioscin in protecting cardiomyocytes against anoxia/reoxygenation injury].

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OBJECTIVE To study the effect and mechanism of methyl protodioscin (MPD), an active ingredients of yamogenin, in protecting cardiomyocytes (CMC) against anoxia/reoxygenation (A/R) injury. METHODS Cultured CMCs of neonatal SD rats were randomly divided into three groups, cells in Group A were

Adenovirus-mediated hypoxia-inducible factor 1alpha double-mutant promotes differentiation of bone marrow stem cells to cardiomyocytes.

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The hypoxia-inducible factor 1alpha (HIF-1alpha) regulates transcriptional genes involved in cell proliferation, survival, and differentiation. Under normoxia, HIF-1alpha has a short half-life (t((1/2)) approximately 5 min) and low transcriptional activity. An HIF-1alpha mutant, produced by

Effect of total flavonoid in rabdosia rubescens on tolerant mice models under cerebral anoxia.

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UNASSIGNED To study the protective effect of total flavonoid in rabdosia rubescens on BIT model by brain ischemic tolerance (hereinafter BIT) model of mice. UNASSIGNED BIT model is used to block bilateral common carotid arteries and to copy BIT model of mice. After 10 min of transient ischemia for

[Interstitial pneumonia after CMC (CDDP, MMC, CPM) therapy].

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Six patients receiving CDDP, MMC, and CPM chemotherapy for adjuvant chemotherapy after a resection due to lung cancer developed interstitial pneumonia. They were re-admitted for dyspnea, shortness of breath, and dry cough from 80 to 118 days from start of their treatment. On re-admission, their

Severe pulmonary hypertension is associated with altered right ventricle metabolic substrate uptake.

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In severe pulmonary hypertension (SPH), prior studies have shown an increase in right ventricle (RV) uptake of glucose, but it is unclear whether there is a change in the relative utilization of fatty acids. We hypothesized that in the RV in SPH, as in left ventricular (LV) failure, there is altered

Impact of surface modification on the toxicity of zerovalent iron nanoparticles in aquatic and terrestrial organisms.

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Nanoscale zerovalent iron (nZVI)-based materials are increasingly being applied in environmental remediation, thereby lead to their exposure to aquatic and terrestrial biota. However, little is known regarding the toxic effects of surface-modified nZVI on multiple species in the ecosystem. In this

Effects of Scrambling trumpet Creeper flavone on transient cerebral ischemia model (TIA) in rats.

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To investigate the effects of Scrambling Trumpet Creeper flavone on neurological function score, brain tissue lesion and related biochemical indexes in rat TIA model. Methods: TIA model was induced by tail vein injection of t-butanol (t-BHP). The rats in each administration group were given large,

Biodiversity of the oleaginous microorganisms in Tibetan Plateau.

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Microbial lipids, which are also known as single cell oils (SCO), are produced by oleaginous microorganisms including oleaginous bacteria, yeast, fungus and algae through converting carbohydrates into lipids under certain conditions. Due to its unique environment having extremely low temperature and

Differential alteration in reproductive toxicity of medaka fish on exposure to nanoscale zerovalent iron and its oxidation products.

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Nanoscale zerovalent iron (nZVI) is a redox-active nanomaterial commonly used in remediation of soil and groundwater pollution and wastewater treatment processes. A large quantity of nZVI (e.g., >100 mg/L) accidentally released from in situ sites to nearby oxygenized aquifers could be rapidly

The zerovalent iron nanoparticle causes higher developmental toxicity than its oxidation products in early life stages of medaka fish.

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Nanoscale zerovalent iron (nZVI)-mediated oxidation reaction is increasingly being used for enhanced treatment of water or wastewater processes; however, the fate and eco-toxicological effects of nZVI in the surface aquifer remain unclear. We investigated bioaccumulation and lethal-to-sublethal

Evaluation of artificial tears on cornea epithelium healing.

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OBJECTIVE To observe the efficacy of different artificial eye drops on corneal epithelium healing in rabbit. METHODS Thirty-five rabbits with 6 mm diameter central corneal epithelium removed were randomly assigned to six groups: 0.9% normal saline (NS) group, 0.1% hyaluronate (HA) group, 0.3% HA

Influence of viscous incubation media on the resistance to diffusion of the intestinal unstirred water layer in vitro.

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Everted sacs of rat intestine were incubated in media made viscous with Na-carboxymethylcellulose (CMC). This increased the resistance to diffusion of the mucosal unstirred water layer, as measured by the half-time for the establishment of osmotic streaming potentials. The increase ws not however

Toxicity assessments of nanoscale zerovalent iron and its oxidation products in medaka (Oryzias latipes) fish.

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Iron-based nanotechnologies are increasingly used for environmental remediation; however, toxicologic impacts of iron nanoparticles on the aquatic ecosystem remain poorly understood. We treated larvae of medaka fish (Oryzias latipes) with thoroughly characterized solutions containing carboxymethyl

Topical rapamycin suppresses the angiogenesis pathways induced by pulsed dye laser: molecular mechanisms of inhibition of regeneration and revascularization of photocoagulated cutaneous blood vessels.

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OBJECTIVE Pulsed dye laser (PDL) is the most effective treatment for port wine stain (PWS) birthmarks. However, regeneration and revascularization of photocoagulated blood vessels may result in poor therapeutic outcome. We have recently shown that rapamycin (RPM), an angiogenesis inhibitor, can

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