The enrolled infants were administered sterile solution of 0.2 ml of 24% sucrose (active control) 2 min prior to procedure.
24% sucrose was prepared by mixing 2.4gm of sucrose in 10ml distilled water.

The enrolled infants were administered 0.2 ml of 12% sucrose 2 min prior to procedure.
These solution were prepared under all sterile precautions by the laboratory staff unrelated to the study. 12%sucrose was prepared by mixing 1.2 gm of sucrose in 10 ml of distilled water. here were two study groups A & B. The enrolled infants were administered sterile solution of 0.2 ml of 24% sucrose (active control) 2 min prior to procedure.
Out of these solutions 1ml was measured by 1 ml syringe and packed and covered with serially numbered opaque sealed envelopes. At the initiation of venepuncture 2 min prior to procedure 0.2 ml of solution marked with patient serial no was administered by a pre-filled syringe to the patient on the anterior aspect of the tongue avoiding spillage, by the personnel carrying out the procedure. The above mentioned personnel was blinded to the contents of the solution.

Neonate

Pain

ELBW

12% Sucrose

24% Sucrose

Sucrose to Reduce Pain During Initiation of Venipuncture in Extremely Low Birth Weight Babies

A Study to Assess the Role of Two Different Concentrations of Sucrose to Reduce Pain During Initiation of Venipuncture in Extremely Low Birth Weight Babies

In Neonatal Facial Coding System, ten actions were monitored which included brow bulge,eye squeeze,deepening of nasolabial furrow, open lips,vertical mouth stretch, horizontal mouth stretch,cupping of tongue,chin quiver,lip pursing to form O,and tongue protrusion.Each facial action was coded as 1 for occurrence and 0 for no occurrence/absence. The final score was assigned by adding these ten parameters.Thus minimum score could be 0 and the maximum score 10 for a preterm infants

The change in the heart rate from the baseline which was measured pre procedure was recorded.It was indicated as beats/minute.

Side effects noted were only the immediate side effects .Total number of neonates in each arm presenting with side effects would be recorded.

DR. VIKRAM DATTA

Professor

Lady Hardinge Medical College

There were two study groups A and B. The enrolled infants were administered either sterile solution of 0.2 ml of 24% sucrose or 0.2 ml of 12% sucrose 2 min prior to the procedure. The procedure involved putting first cannula in the dorm of the right hand. A 24 G needle was inserted into the vein after asepsis 2 min after the neonate had been given the allocated solution. The process was divided into three phases, the pre procedure, intraprocedure and post procedure lasting for 4 minutes. Video recording on the face of the neonate was done using a fixed video camera. The NFCS was used to evaluate and score neonatal pain.It was scored at pre, intra and post procedure 30 sec, 1 min and 2 min of the procedure.

This arm will be given 5mg tablets of Melatonin nightly for the duration of their hospital stay

This arm will be given 3mg tablets of Melatonin nightly for the duration of their hospital stay

This arm will be given a Sucrose tablet nightly for the duration of their hospital stay

sucrose/seizures

Sucrose to Reduce Pain During Initiation of Venipuncture in Extremely Low Birth Weight Babies

Melatonin Use in the Intensive Care Elderly Population

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