theophylline/seizures

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Grand mal seizure induced by oral theophylline.

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A grand mal convulsion occurred in a patient with decompensated cor pulmonale. Although only modest doses of oral theophylline were being administered at the time of the convulsion the serum theophylline level was markedly raised and the theophylline clearance was very low. After treatment for cor

Theophylline-induced seizures in accidentally overdosed neonates.

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Theophylline-induced seizures are reported in two neonates. The serum theophylline concentration during seizures were 51.0 mg/liter and 54.0 mg/liter. Toxic symptoms prior to seizures may be absent or undetected, suporting the necessity of blood level monitoring during theophylline therapy.

Seizures due to theophylline overdose.

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We report two cases of seizure activity due to theophylline overdose with serum levels of theophylline of 26 and 26.3 micrograms/dl. Both patients had evidence of prior neurologic damage. A review of the literature is presented with discussion of the possible mechanism of this reaction at relatively

Theophylline-associated seizures in children.

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Four patients are reported who experienced seizures in association with serum theophylline concentrations which were in the mildly toxic range. In three patients, erythromycin administration was a probable factor contributing to the elevated theophylline levels. One patient suffered severe

Predisposing factors to apparent theophylline-induced seizures.

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Fifteen patients experienced theophylline-related seizures at our institution over the past 3 years. Thirteen of the patients were receiving oral maintenance theophylline therapy while two patients were on IV therapy at the time of their episode. The serum theophylline concentration (STC) obtained

Theophylline reversal of electroconvulsive therapy (ECT) seizure inhibition.

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Oral sustained-release theophylline 200-400 mg, given 10 hours prior to electroconvulsive therapy (ECT) increased ECT seizure length in each of eight male patients who had shown unacceptably short seizures. The increase was on average 13.9 (+/- 6.0, SD) sec (p = .00016 by t test; p = .0000034 by

[Case of an 81-year-old woman with theophylline-associated seizures followed by partial seizures due to vitamin B6 deficiency].

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We report an 81-year-old woman who suffered from theophylline-associated seizures followed by partial seizures due to vitamin B6 deficiency. She developed complex partial seizures. She had been treated with theophylline for two months because of chronic bronchitis. Brain diffusion-weighted magnetic

Impact of an oral theophylline loading dose pre-electroconvulsive therapy: a retrospective study in patients with missed or inadequate seizures.

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OBJECTIVE The aim of this study was to determine the safety and impact of an oral theophylline loading dose calculated to achieve a 10- to 15-mg/L plasma concentration when administered 1.5 hours before electroconvulsive therapy (ECT). METHODS We conducted a retrospective study using inpatient

Theophylline-induced seizures in a 6-month-old girl. Serum and cerebrospinal fluid levels.

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The case is presented of a 6-month-old girl with theophylline-induced focal seizures associated with tachycardia, tremor and irritability. The serum level of theophylline was 20.0 micrograms/ml 30 min after the onset of seizures, and declined to half this level at 19 h. The ratio of the

Kinetics of drug action in disease states. XXVI: Effect of fever on the pharmacodynamics of theophylline-induced seizures in rats.

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This investigation was designed to determine the effect of fever on the neurotoxicity of theophylline as reflected by the concentrations of this drug that cause convulsions in experimental animals. Fever was produced in male, inbred, adult Lewis rats (approximately 180 g) by sc injection of brewer's

[A clinical review of patients with convulsions during theophylline administration II: points to consider in administration and prognosis as determined in patients with theophyline toxicosis].

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OBJECTIVE To discover features of patients with theophylline toxicosis among patients who developed convulsions during theophylline administration. METHODS Fifteen patients, whose measured or estimated blood theophylline concentration at the time of convulsion development was >/=40 microg/mL, were

[A case of theophylline-associated seizures with postictal fever and postictal pleocytosis].

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We report a 70-year-old man who developed theophylline-associated seizure with postictal fever and postictal pleocytosis. He was admitted to our hospital for a left hemiconvulsion lasting for two hours. The concentration of theophylline was high (21.6ng/ml), and electroencephalogram demonstrated

Intravenous theophylline is the most effective intervention to prolong EEG seizure duration in patients undergoing electroconvulsive therapy.

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BACKGROUND Seizure duration in electroconvulsive therapy (ECT) is positively related with patients' outcome. This study sought to investigate the impact of anesthetic management on seizure duration, and the impact of selected drugs (theophylline, remifentanil, S-ketamine) on seizure

Seizures during concomitant treatment with theophylline and ranitidine: a case report.

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H2-antagonists such as cimetidine and ranitidine are metabolized by cytochrome P-450. In this way they may interfere with theophylline metabolism. Cimetidine is known to have this effect and frequently to induce a theophylline toxic effect, while data concerning ranitidine are more uncertain. In

Interaction of theophylline with erythromycin base in a patient with seizure activity.

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A pediatric patient who was taking carefully monitored doses of theophylline for chronic asthma, was placed on erythromycin base for bronchitis. She subsequently developed theophylline toxicity which caused her to experience seizure activity. Any patient taking a theophylline preparation who is then

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