All patients receive 10 acupuncture treatments over the course of 8 weeks.

Chemotherapy-induced Peripheral Neuropathy

Breast Cancer Female

Gynecologic Cancer

The manualized acupuncture treatment (AT) intervention will be designed by Dr. Budhathoki and Dr. Taylor-Swanson and administered by Dr. Budhathoki and members of Huntsman acupuncture team. Ten sessions of AT will be delivered: twice per week for 2 weeks, thereafter once per week for six weeks, with a total of 9 treatments during a two-month course. Each session will last 45-60 minutes, with acupuncture needles retained 30-40 minutes. A minimum of 8 treatments must be received by each participant with no more than 9 days' gap between treatments permitted. Concurrent medications are allowed as prescribed and will be tracked in the study and analyzed as potential confounders.
Participants in the study will undergo study interview and fMRI at the following two time points: within 9 days after baseline following enrollment and within one week of acupuncture treatment completion.

Acupuncture

Huntsman Cancer Institute

Acupuncture Treatment of Chemotherapy-Induced Peripheral Neuropathy in Women

Acupuncture Treatment of Chemotherapy-Induced Peripheral Neuropathy in Women With Breast or Gynecologic Cancers: Mechanisms of Action and Feasibility

Average of 2 eligible women per month to participate in the trial

70% or more participants comply with AT attendance defined as 8 or more of 10 AT sessions and complete both fMRI scans

Zero serious adverse events directly related to AT sessions

70% or more enrolled participants comply with data collection

Lisa J Taylor-Swanson

Assistant Professor

University of Utah

Transnasal blockade of SPG approach involving the application of 2 cc (approximately the size of a pea) of 2% lidocaine jelly on a cotton swab directed posteriorly towards the SPG in the nasal passage bilaterally. Cotton swab will be inserted to the back of the nasal passage until it can no longer be inserted any further. The cotton swab should remain in place for 15 minutes on both sides simultaneously. The patient will be instructed on how to perform this procedure on themselves, and they will be given supplies for a 7-day supply of medication to be administered two times per day at approximately 12 hour intervals.

Transnasal blockade of SPG approach involving the application of 2 cc (approximately the size of a pea) of nasal saline jelly on a cotton swab directed posteriorly towards the SPG in the nasal passage bilaterally. Cotton swab will be inserted to the back of the nasal passage until it can no longer be inserted any further. The cotton swab should remain in place for 15 minutes. The patient will be instructed on how to perform this procedure on themselves, and they will be given supplies for a 7-day supply of medication to be administered up to two times per day at approximately 12 hour intervals.

Post-Dural Puncture Headache

Patients will be prescribed a regimen of 1 g acetaminophen q 8hrs alternating with 600 mg ibuprofen q 6 hours. In addition they will be instructed to continue oral fluid hydration and minimal activity for 24 hours.
At 2-hours following the SPG blockade an EBP will be offered to patients. Patient will also be informed that they can request an EBP at any time. The SPG blockade will be performed twice daily in the hospital and twice daily at home, by the patient. The patient will also be informed, if that at anytime, they would like an EBP, it can be provided.
While the study is being conducted, patients will not be offered a SPG block unless enrolled in the study.

Lidocaine HCl Gel 2%

placebo gel

RCT of SPG Blocks for Post-dural Headache

A Multicenter Double Blinded Randomized Controlled Trial of the Efficacy of the Sphenopalatine Ganglion Block for the Treatment of the Postdural Puncture Headache After Labor Epidural

Proportion of postpartum women with a postdural puncture headache (PDPH) requesting epidural blood patch (EBP)

Daily Questionnaire regarding functionality

University of Colorado, Denver

University of California, San Francisco

Duke University

Mayo Clinic

Harvard University

Postoperative Quality of Recovery

Postoperative Migrainous Headache

Single subcutaneous injection sumatriptan 6mg (in 0.5ml) in recovery

Sumatriptan

Single injection saline 0.5ml subcutaneously in recovery

trigeminal neuralgia/bulantı

Acupuncture Treatment of Chemotherapy-Induced Peripheral Neuropathy in Women

RCT of SPG Blocks for Post-dural Headache

Effect of Sumatriptan on the Postoperative Quality of Recovery After Elective Minimally Invasive Craniotomy

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