xylitol/kanser

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Xylitol acts as an anticancer monosaccharide to induce selective cancer death via regulation of the glutathione level.

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Herbal medicines and their bioactive compounds are increasingly being recognized as useful drugs for cancer treatments. The parasitic fungus Cordyceps militaris is an attractive anticancer herbal since it shows very powerful anticancer activity due to its phytocompound cordycepin. We previously

Xylitol induces cell death in lung cancer A549 cells by autophagy.

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Xylitol is a widely used anti-caries agent that has anti-inflammatory effects. We have evaluated the potential of xylitol in cancer treatment. It's effects on cell proliferation and cytotoxicity were measured by MTT assay and LDH assay. Cell morphology and autophagy were examined by immunostaining

Partial Substitution of Glucose with Xylitol Suppressed the Glycolysis and Selectively Inhibited the Proliferation of Oral Cancer Cells.

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Suitable diet for cancer survivors remains an unresolved challenge. Increased glucose utilization is a hallmark of various cancers. Therefore, alternative carbohydrate supplying normal tissue but retarding cancer growth is needed. This study investigated the effect of sugar alcohols on the

Novel olive oil phenolic (-)-oleocanthal (+)-xylitol-based solid dispersion formulations with potent oral anti-breast cancer activities.

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Epidemiological studies have compellingly documented the ability of the Mediterranean diet rich in extra-virgin olive oil to reduce the incidence of certain malignancies, and cardiovascular diseases, and slow the Alzheimer's disease progression. S-(-)-Oleocanthal (OC) was identified as the most

[Studies on the prevention of side-effects of the anti-cancer agent, mitomycin C by xylitol].

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Vitamin D3, lactose, and xylitol stimulate chromaffin cell proliferation in the rat adrenal medulla.

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Chronic consumption by rats of diets rich in sugars or sugar alcohols leads to an increased incidence of pheochromocytomas. This relationship is hypothesized to be based on altered Ca2+ homeostasis due to increased intestinal Ca2+ absorption. Other agents associated with pheochromocytomas in rats in

Antitumour action of 1,5-dihalogeno-, and 1, 2-4, 5-dianhydro-xylitol derivatives.

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The antitumour action of some xylitol compounds possessing alkylating potency at 1 and 5 position of the sugar skeleton was investigated. Unlike the hexitol derivatives, bi-halogenated xylitols showed no antitumour action. The modest therapeutic index of 1, 2-4,5-dianhydroxylitol on the NK/Ly

[An early phase II clinical study of cis-diammine glycolato platinum, 254-S, for head and neck cancers].

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An early phase II clinical study of 254-S, a new anticancer platinum complex, for head and neck cancer was conducted by the 254-S Head and Neck Cancer Study Group consisting of 10 institutions. Based on the results obtained in the phase I study, 254-S was administered at 100 mg/m2 by 60 min

[Renal oxalosis with renal failure after infusion of xylitol].

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METHODS Ten days after a complication-free operation for early gastric cancer a 61-year old man had a seizure and acute renal failure. METHODS A percutaneous renal biopsy was performed to find the cause of the renal failure, which at times required several sessions of haemodialysis. METHODS The

Determination of glutathione in apoptotic SMMC-7221 cells induced by xylitol selenite using capillary electrophoresis.

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OBJECTIVE To determine the glutathione (GSH) content in a human hepatoma cell line (SMMC-7221) treated with xylitol/selenite, providing a part of an investigation of its anti-cancer mechanisms. RESULTS The nuclei of SMMC-7221 cells were stained with Hoechst 33258 in an apoptosis assay, and their

Identification of a novel component leading to anti-tumor activity besides the major ingredient cordycepin in Cordyceps militaris extract.

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In accordance with our previous study that was carried out to identify novel anti-tumor ingredients, chromatographic separation in combination with an anti-tumor activity assay was used for analysis of Cordyceps militaris extract in this study. Various modes of chromatography including

Anti-irritant and anti-inflammatory effects of glycerol and xylitol in sodium lauryl sulphate-induced acute irritation.

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BACKGROUND Glycerol is known to possess anti-irritant and hydrating properties and previous studies suggested that xylitol may also have similar effects. OBJECTIVE Our aim was to study whether different concentrations of these polyols restore skin barrier function and soothe inflammation in sodium

Xylitol, an anticaries agent, exhibits potent inhibition of inflammatory responses in human THP-1-derived macrophages infected with Porphyromonas gingivalis.

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BACKGROUND Xylitol is a well-known anticaries agent and has been used for the prevention and treatment of dental caries. In this study, the anti-inflammatory effects of xylitol are evaluated for possible use in the prevention and treatment of periodontal infections. METHODS Cytokine expression was

The relation of clinical catastrophes, endogenous oxalate production, and urolithiasis.

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A dose-related toxicity syndrome of renal, cerebral, and liver dysfunction; metabolic acidosis; and deposition of calcium oxalate crystals in tissues is reported in association with various apparently unrelated treatments for a wide range of diseases. The parenteral nutrient xylitol, the

[Phase I study of a new platinum complex 254-S, cis-diammine (glycolato)-platinum (II)].

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A new platinum complex 254-S had a superior preclinical therapeutic indices compared to cisplatin, showing decreased renal and gastrointestinal toxicities. Phase I clinical study with a single dose schedule was conducted to investigate the safety, toxicity, pharmacokinetics and possible efficacy

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