[Activity of lysosomal enzymes in rabbit brain during the development of edema].

Liberation and consequent activation of lysosomal enzymes seems to play significant role in the development of brain edema. In the present experiment with adult rabbits, anesthetized with urethane we investigated in the brain tissue homogenates the activity of four lysosomal enzymes, such as desoxyribonuclease, ribonuclease, katepsine D and acid phosphatase following the development of osmotic brain edema as well as in control animals. The activities of the lysosomal enzymes were investigated with a spectrophotometric technique. Experiments showed that the activity of lysosomal enzymes increased sharply during development of brain edema. Thus the obtained results demonstrate the behaviour of activity of the lysosomal enzymes in the brain tissue during development of brain edema and a way of normalization of these processes.