[Anti-tumor activity of the polysaccharide mannan, and its effect on the dynamics of cyclic nucleotides in tissue].

Mice with transplantable Harding-Passey melanoma were treated with polysaccharide mannan (50 mg/kg), cyclophosphamide (20 and 100 mg/kg) and their combinations. Mannan proved to possess considerable antitumor properties. It potentiated the therapeutic effect of cyclophosphamide and diminished its toxicity. Mannan treatment resulted in two-phase dynamics of cyclic nucleotide system in mouse liver and melanoma.