The role of cervical pessary and progesterone therapy in the phenomenon of placenta previa migration.
Ключові слова
Анотація
OBJECTIVE
This study aimed to evaluate the effects of combined management of placenta previa with the Arabin cervical pessary and progesterone.
METHODS
In this randomized controlled study, we followed up 217 patients with placenta previa and high risk of preterm birth. The main group (n = 81) underwent combined management with the Arabin cervical pessary and progesterone; the control group (n = 136) received progesterone only. Placental migration was monitored using Doppler scanning from 24 weeks of pregnancy onwards.
RESULTS
Patients receiving the combination of the Arabin cervical pessary and progesterone had a three-fold reduced rate of bleeding during pregnancy compared with patients in the control group (11.3 versus 33.1%; p = 0.006). Placental migration occurred 1.8 times more often in the pessary group (48.1 versus 26.4%; p = 0.037), and preterm labor < 34 weeks occurred 2.7 times less often compared with the control group (p = 0.031). The use of the Arabin cervical pessary caused a change in the anterior cervico-uterine angle by 7.4 degrees, and reduction in the arcuate artery resistance index (RI) at 32-33 weeks of pregnancy compared with the control group.
CONCLUSIONS
The use of the Arabin cervical pessary combined with progesterone in patients with placenta previa significantly reduced the rate of preterm delivery < 34 weeks and bleeding during pregnancy.
