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DESCRIPTION OF RELATED APPLICATIONS
This application claims priority under 35 U.S.C. .sctn. 119 to Japanese Patent Application No. 2002-248586 filed on Aug. 28, 2002, Japanese Patent Application No. 2002-364725 filed on Dec. 17, 2002, U.S. Provisional Application Ser. No. 60/407291 filed Sep. 3,
This application is a national stage entry under 35 U.S.C. .sctn.371 of PCT/JP05/03686, filed Feb. 25, 2005.
TECHNICAL FIELD
The present invention relates to a novel benzothiazepine or benzothiepine compound having a thioamide bond and a quaternary ammonium substitutent, and a pharmaceutical
FIELD OF THE INVENTION
The invention concerns relates to compounds that modulate TGR5 and compositions useful in methods for the treatment and/or prevention of various diseases.
BACKGROUND OF THE INVENTION
TGR5 receptor is a G-protein-coupled receptor that has been identified as a cell-surface
RELATED APPLICATIONS
This application is a 35 U.S.C. .sctn.371 National Phase Application of PCT/US2008/000658, filed Jan. 18, 2008, which claims priority from EP07001143.2, filed Jan. 19, 2007 and EP07012079.5, filed Jun. 20, 2007, each of which is incorporated by reference in its entirety.
FIELD