Transdermal Nicotine Patch + Progesterone (200 mgs BID)

Transdermal Nicotine Patch + Placebo (for Progesterone)

Transdermal Nicotine Patch + Progesterone (200 mgs BID)
Progesterone (200 mgs BID): TNP + Progesterone

TNP + Progesterone

Transdermal Nicotine Patch + Placebo (for Progesterone)
Placebo: TNP + Placebo

TNP + Placebo

Total

Sex: Female, Male

Ethnicity (NIH/OMB)

Race/Ethnicity, Customized

Cigarettes per day

Participants were asked on a scale from 1 (not motivated at all) to 10 (extremely motivated), how motivated are you to quit smoking?

Motivation to quit smoking

Lives with smoker

The 7-day point prevalence is defined by self-reported smoking abstinence for the last 7 days.

7-day Point Prevalence of Smoking Abstinence

Carbon Monoxide <10 Ppm

The Stroop test assesses cognitive processing. The Level 3 Stroop Throughput score incorporates both accuracy and speed. In Level 3 of the Stroop test, a series of words representing colors are shown in a font color that is incongruent with the word (e.g. RED would be shown in blue font). Users are asked to press a response key associated with the color of the font, not the written word. Quicker and more accurate responses lead to higher scores. The lowest possible score is 0 (no correct responses). There is no defined maximum score, as the score depends upon both response time and number of correct responses. A Level 3 Stroop Throughput change score was calculated by subtracting baseline score from week 2 score. Higher positive scores represent greater improvement in scores at week 2 relative to baseline, and lower negative scores represent greater decline in scores from baseline to week 2.

Change in Stroop Measure of Inhibitory Function

Week 2 minus baseline. This task assesses the ability to withhold responses to an infrequently occurring target (No-Go trials). A total of 225 single digits (25 x 9 digits) are presented on a computer monitor for 250 ms each, immediately followed by a mask for 900 ms. Subjects must press a spacebar in response to every digit except the "3".
Go/No Go score is calculated as separation between the means of the signal and the noise distributions and is reported in standard deviation units, representing an overall indicator of performance since it accounts for correct responses and incorrect responses. Higher scores represent a better outcome. For the change score, higher positive scores represent greater improvement in scores between baseline and week 2, and lower negative scores represent greater decline in scores between baseline and week 2.

Change in Go/No Go Task Measure of Inhibitory Function

The Code Substitution Test (a computerized adaptation/variant of the Digit Symbol Substitution Test) is a test of psychomotor performance. The Code Substitution-Learning Throughput Score incorporates both accuracy and speed. During the learning phase of this test, users are continuously shown a row of 9 digits that are paired with a symbol (the pairings are constant). Users are presented with a series of individual pairings and are asked to press a response key to indicate if the pairing is correct or not. Quicker and more accurate responses lead to higher scores. The lowest possible score is 0 (no correct responses). There is no defined maximum score, as the score depends upon both response time and number of correct responses. A change score was calculated by subtracting baseline score from week 2 score. Higher positive scores represent greater improvement in scores at week 2 relative to baseline, and lower negative scores represent greater decline in scores from baseline to week 2.

Transdermal Nicotine Patch + Progesterone (200 mgs BID)
Progesterone (200 mgs BID): Transdermal Nicotine Patch (TNP) + Progesterone

Change in Digit Symbol Task Measure of Inhibitory Function

The PANAS questionnaire consists of 20 items that describe different feelings and emotions. Participants are asked to what extent they feel this way right now on 5-point scale ranging from 1 (very slightly or not at all) to 5 (extremely). Separate Positive Affect Scores and Negative Affect Scores were calculated from 10 items each. Scores can range from 10 t0 50, with higher scores representing higher levels of positive affect and with lower scores representing lower levels of negative affect.

Positive and Negative Affect Schedule (PANAS) Total Score

Abstinence from 2 weeks post quit date to the one month follow up

Prolonged Abstinence Post Trial

Abstinence from 2 weeks post quit date to 3 month follow up (total of 6-8 weeks during the trial and 3 month follow up)

Prolonged Abstinence Follow up

Treatment Period

1-Month Follow-Up

3-Month Follow-Up

Kimberly Yonkers, MD

Smoking Cessation

Transdermal Nicotine Patch (TNP) + Progesterone

Progesterone (200 mgs BID)

Placebo

Yale School of Medicine, Department of Psychiatry

Progesterone Augmentation of Nicotine Replacement Therapy Study

we will only make aggregate de-identified data available

Yale University

National Cancer Institute (NCI)

blood, omentum, endometrium, adipose tissue

Morbid Obesity

Endometrial Pathology

Menstrual Irregularities

University of Virginia

Study of Menstrual Irregularities and Endometrial Pathology in Women Undergoing Bariatric Surgery

Prevalence of Menstrual Irregularities and Endometrial Pathology in Women Who Are Candidates for Bariatric Surgery: Correlation With Perceived Risk, Biomarkers, and Weight Loss

endometrial hyperplasia/нікотин

Progesterone Augmentation of Nicotine Replacement Therapy Study

Study of Menstrual Irregularities and Endometrial Pathology in Women Undergoing Bariatric Surgery

Найповніша база даних про лікарські трави, підкріплена наукою