9 результати
TECHNICAL FIELD
This disclosure relates to malate salts of N-(4-{[6,7-bis(methyloxy)-quinolin-4-yl]oxy}phenyl)-N'-(4-fluorophenyl)cy- clopropane-1,1-dicarboxamide and to crystalline and amorphous forms of the malate salts of N-(4-{[6,7-bis(methyloxy)-quinolin-4-yl]oxy}phenyl)-N'-(4-fluorophenyl)cy-
REFERENCE OF PRIOR ART
U.S. Pat. No. 3,862,010 issued Jan. 21, 1975.
U.S. Pat. No. 4,003,795 issued Jan. 18, 1977.
Publication cited in U.S. Pat. No. 4,311,791.
The method disclosed herein is applicable to automated instruments which is a heretofore unanswered need in the art as noted by the
TECHNICAL FIELD
This disclosure relates to malate salts of N-(4-{[6,7-bis(methyloxy)-quinolin-4-yl]oxy}phenyl)-N'-(4-fluorophenyl)cy- clopropane-1,1-dicarboxamide and to crystalline and amorphous forms of the malate salts of N-(4-{[6,7-bis(methyloxy)-quinolin-4-yl]oxy}phenyl)-N'-(4-fluorophenyl)cy-
BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention relates to a novel lipid emulsion having the activity of potentiating the anti-cancer activity of an anti-cancer agent, a method of potentiating the activities of anti-cancer agents by using it with the lipid emulsion, and to a
BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention relates to a novel lipid emulsion having the activity of potentiating the anti-cancer activity of an anti-cancer agent, a method of potentiating the activities of anti-cancer agents by using it with the lipid emulsion, and to a
BACKGROUND OF THE INVENTION
Although there have been great improvements in the diagnosis and treatment of cancer, many people die from cancer each year, and their deaths are typically due to metastases and cancers that are resistant to conventional therapies.
Most drug-mediated cancer therapies rely
FIELD OF THE INVENTION
The invention relates to novel crystalline solid forms of the chemical compound N-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-N'-(4-fluorophenyl- ) cyclopropane-1,1-dicarboxamide, and solvates thereof, including hydrates, that are useful for the treatment of cancer. Also
BACKGROUND OF THE INVENTION
Cell death is a feature of many diseases as well as therapeutic methods, for example in the treatment of cancer. It is therefore desirable to be able to measure cell death, to assess either the status of a disease that involves cell death or the effect of a treatment that
The following examples illustrate the present invention, but it is to be understood that they are given for the purpose of illustration and not limitation.
EXAMPLE 1
A medium (100 l) containing 6.0% soluble starch, 4.0% cotton seed meal, 0.2% (NH.sub.4).sub.2 SO.sub.4, 0.1% yeast extract, 0.2%