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BACKGROUND OF THE INVENTION
Diseases caused by elevated levels of uric acid fall into two major categories: disorders caused by precipitation of uric acid crystals and diseases related to pathological effects of soluble uric acid. Gouty arthritis is the classic example of the former. Deposition of
BACKGROUND OF THE INVENTION
Diseases caused by elevated levels of uric acid fall into two major categories: disorders caused by precipitation of uric acid crystals and diseases related to pathological effects of soluble uric acid. Gouty arthritis is the classic example of the former. Deposition of
BACKGROUND OF THE INVENTION
Diseases caused by elevated levels of uric acid fall into two major categories: disorders caused by precipitation of uric acid crystals and diseases related to pathological effects of soluble uric acid. Gouty arthritis is the classic example of the former. Deposition of
This application is a U.S. National Stage application of PCT/EP2009/062159, filed Sept. 18, 2009, which claims priority to European Patent Application No. 083055657, filed Sept. 18, 2008, each and all of which are incorporated herein by reference in their entirety.
The present invention is directed
This invention relates to a novel method for the preparation of 7-chloro-2-methyl-3,3a-dihydro-2H,9H-isoxazolo (3,2-b) (1,3) benzoxazin-9-one.
Prior to the present invention, 6-chloro-2-methyl-3,3a-dihydro-2H,9H-isoxazolo (3,2-b) (1,3) benzoxazin-9-one has been prepared by the reaction of
CROSS-REFERENCE TO RELATED APPLICATIONS
This application is a national stage application under 35 U.S.C. .sctn. 371 of PCT/CN2016/000061, filed Jan. 28, 2016, which claims priority to Chinese Application Nos.: 201510048096.3, filed Jan. 30, 2015; 201510079809.2, filed Feb. 13, 2015; 201510080714.2,
This is a national stage application under 35 U.S.C. .sctn.371 of PCT/JP2005/015549 filed on Aug. 26, 2005, which claims priority from Japanese patent application P.2004-249275 filed on Aug. 27, 2004 and from Japanese patent application P.2005-078222 filed on Mar. 17, 2005, all of which are
TECHNICAL FIELD
The present invention relates to a 2-phenylthiophene derivative useful as a medicament, particularly a therapeutic or preventive agent for diseases in which xantine oxidase participates, such as hyperuricemia, gout, inflammatory bowel diseases, diabetic kidney diseases, and diabetic
BACKGROUND OF THE INVENTION
The present invention relates to novel pharmaceutical compositions containing as the active ingredient the compound 5-methyl-1-phenyl-2-(1H)-pyridone (AMR-69) having the formula
Certain substituted pyridones and particularly those wherein the N-substituents are