Effects of (Licochalcone A) and Paclitaxel on Human Oral Squamous Cell Carcinoma Cell Line
Từ khóa
trừu tượng
Sự miêu tả
Oral squamous cell carcinoma (OSCC) is considered the most common human body malignant tumor. It has poor prognosis regarding its distant lymph node metastasis and local destruction which lead to low survival rate.
Paclitaxel is a chemotherapeutic drug of the taxols group that is used in the treatment of lung, ovarian and prostate cancer. It is also used to treat breast, head and neck cancer as well as sarcoma and leukemia. Recent studies and researches explored that Paclitaxel has an important role in mitotic arrest activation and induction, which subsequently lead to cell death.
The conventional treatment strategies such as surgery, radiotherapy and chemotherapy come with low levels of expectations regarding prognosis and survival rate. On the other hand, serious side effects of chemotherapy such as renal toxicity, gastrointestinal upset and bone marrow suppression remain hazards which cannot be avoided.Thus, there is a great need to discover new agents and strategies for treating OSCC or even enhancing the effect of chemotherapy in order to reduce the dose given.
Licorice extract, Licochalcone A, is one of many natural extracts of Glycyrrhiza inflata plant. It has been used in treatment of inflammation, infections and cancer.
ngày
| Xác minh lần cuối: | 08/31/2017 |
| Đệ trình đầu tiên: | 09/11/2017 |
| Đăng ký ước tính đã được gửi: | 09/21/2017 |
| Đăng lần đầu: | 09/25/2017 |
| Cập nhật lần cuối được gửi: | 09/21/2017 |
| Cập nhật lần cuối đã đăng: | 09/25/2017 |
| Ngày bắt đầu nghiên cứu thực tế: | 10/31/2017 |
| Ngày hoàn thành chính ước tính: | 08/31/2018 |
| Ngày hoàn thành nghiên cứu ước tính: | 03/31/2019 |
Tình trạng hoặc bệnh tật
Can thiệp / điều trị
Dietary Supplement: Licochalcone A
Drug: Paclitaxel
Giai đoạn
Nhóm cánh tay
| Cánh tay | Can thiệp / điều trị |
|---|---|
| Experimental: Licochalcone A Licochalcone A is a chalconoid, a type of natural phenols. It can be isolated from root of Glycyrrhiza glabra (liquorice) or Glycyrrhiza inflata. It shows antimalarial, anticancer, antibacterial and antiviral (specifically against influenza neuraminidase) properties. | Dietary Supplement: Licochalcone A Licochalcone A is a chalconoid, a type of natural phenols. It can be isolated from root of Glycyrrhiza glabra (liquorice) or Glycyrrhiza inflata. It shows antimalarial, anticancer, antibacterial and antiviral (specifically against influenza neuraminidase) properties in vitro. |
| Active Comparator: Paclitaxel chemotherapeutic drug | Drug: Paclitaxel chemotherapeutic drug |
Đủ tiêu chuẩn
| Giới tính đủ điều kiện để nghiên cứu | All |
| Chấp nhận tình nguyện viên lành mạnh | Đúng |
| Tiêu chí | Inclusion Criteria: 1. All head and neck squamous cell carcinoma cell lines 2. Licochalcone extracts 3. Taxols group of chemotherapy Exclusion Criteria: 1. Animal experimental studies 2. Any cancer cell line other than squamous cell carcinoma cell lines. 3. Any chemotherapeutics other than Taxols group. |
Kết quả
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